Novel mediators of breast cancer bone metastasis-insights from studies of gene-regulation and the global proteome.
作者信息
Brown Janet E, Wood Steven L
机构信息
Department of Oncology & Metabolism, Weston Park Hospital, Sheffield, UK.
Department of Oncology and Metabolism, The Medical School, Sheffield, UK.
出版信息
Ann Transl Med. 2018 Nov;6(Suppl 1):S71. doi: 10.21037/atm.2018.10.41.
Abstract
摘要
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CAPG enhances breast cancer metastasis by competing with PRMT5 to modulate STC-1 transcription.CAPG 通过与 PRMT5 竞争来调节 STC-1 转录，从而增强乳腺癌转移。
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Depletion of carbonic anhydrase IX abrogates hypoxia-induced overexpression of stanniocalcin-1 in triple negative breast cancer cells.碳酸酐酶 IX 的耗竭可消除缺氧诱导的三阴性乳腺癌细胞中 1 型 STC 的过度表达。
Cancer Biol Ther. 2017 Aug 3;18(8):596-605. doi: 10.1080/15384047.2017.1345390. Epub 2017 Jun 30.
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