Sang Guo-Yao, Chen Zhao-Yun, Meng Cun-Ren, Tian Tian, Zhang Zhao-Xia
Laboratory Medicine Diagnostic Center, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
School of Public Health, Xinjiang Medical University, Urumqi, China.
Open Med (Wars). 2018 Dec 24;13:534-538. doi: 10.1515/med-2018-0078. eCollection 2018.
We assessed the correlation between serum carbohydrate antigen 125 (CA125) and carotid intima-media thickness (cIMT) in patients with coronary artery disease (CAD).
We collected 518 CAD patients from the cardiovascular disease center in our hospital, and all cIMT values were measured in patients with CAD.
The serum CA125 concentrations were found to be increased in CAD patients with early carotid atherosclerosis compared with patients without early carotid atherosclerosis (20.1±7.72 vs. 17.7±6.41 U/mL, p<0.001). The cIMT values were increased in patients with higher serum CA-125 levels than those with lower serum CA-125 concentrations (1.16±0.32 vs. 0.98±0.29 mm, p<0.001). There was a positive correlation between serum CA125 and cIMT in CAD patients (r=0.262, p<0.001). Moreover, the serum CA125 concentrations also were positively correlated with cIMT in subjects with early carotid atherosclerosis and without early carotid atherosclerosis (r=0.255, p<0.001; r=0.189, p=0.002). We found that serum CA-125 concentrations were independently correlated with cIMT (beta = 0.293, p<0.001) in multiple linear regression analysis.
We found that serum CA125 concentrations were positively correlated with cIMT in CAD patients, serum CA125 might be a potential biochemical marker for the estimation of atherosclerosis in patients with CAD.
我们评估了冠心病（CAD）患者血清糖类抗原125（CA125）与颈动脉内膜中层厚度（cIMT）之间的相关性。
我们从我院心血管疾病中心收集了518例CAD患者，并对所有CAD患者测量了cIMT值。
与无早期颈动脉粥样硬化的患者相比，有早期颈动脉粥样硬化的CAD患者血清CA125浓度升高（20.1±7.72 vs. 17.7±6.41 U/mL，p<0.001）。血清CA-125水平较高的患者cIMT值高于血清CA-125浓度较低的患者（1.16±0.32 vs. 0.98±0.29 mm，p<0.001）。CAD患者血清CA125与cIMT之间存在正相关（r=0.262，p<0.001）。此外，在有早期颈动脉粥样硬化和无早期颈动脉粥样硬化的受试者中，血清CA125浓度也与cIMT呈正相关（r=0.255，p<0.001；r=0.189，p=0.002）。我们发现在多元线性回归分析中，血清CA-125浓度与cIMT独立相关（β = 0.293，p<0.
