从该真菌中提取的三种对钾通道Kv1.3具有抑制作用的新型苯基螺二氢愈创木烷衍生物。
Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus .
作者信息
Feng Jia-Min, Li Min, Zhao Jin-Lian, Jia Xiao-Na, Liu Ji-Mei, Zhang Min, Chen Ri-Dao, Xie Ke-Bo, Chen Da-Wei, Yu Hai-Bo, Dai Jun-Gui
机构信息
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
b Key Laboratory of Biosynthesis of Natural Products of National Health Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
出版信息
J Asian Nat Prod Res. 2019 Sep;21(9):887-894. doi: 10.1080/10286020.2018.1551372. Epub 2019 Jan 5.
Three new phenylspirodrimanes derivatives named stachybotrysins H and I ( and ) and stachybotrin E (), together with one known compound stachybotrylactam (), were isolated from CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds and showed inhibitory effect towards potassium channel Kv1.3 with IC values of 13.4 and 10.9 μM, respectively.
从中国普通微生物菌种保藏管理中心3.5365号菌株中分离出三种新的苯基螺二氢苊衍生物，分别命名为葡萄穗霉毒素H和I（ 和 ）以及葡萄穗霉毒素E（ ），同时还分离出一种已知化合物葡萄穗霉内酰胺（ ）。通过广泛的核磁共振数据和质谱分析确定了它们的结构。化合物 和 对钾通道Kv1.3显示出抑制作用，其半数抑制浓度（IC）值分别为13.4和10.9 μM。
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