从深海来源真菌葡萄穗霉属菌株MCCC 3A00409中分离得到的两种新型苯基螺旋二萜类化合物。
Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409.
作者信息
Ma Xin-Hua, Zheng Wei-Min, Sun Kai-Hui, Gu Xiao-Fan, Zeng Xian-Ming, Zhang Hai-Tao, Zhong Tian-Hua, Shao Zong-Ze, Zhang Yong-Hong
机构信息
a Fujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University , Fuzhou , P.R. China.
b Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration , Xiamen , P.R. China.
出版信息
Nat Prod Res. 2019 Feb;33(3):386-392. doi: 10.1080/14786419.2018.1455041. Epub 2018 Mar 23.
Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2-8, 10-13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9-12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC in the range of 18.5-52.8 μM.
从深海来源的曲霉属真菌MCCC 3A00409中分离出两种新的苯基螺二氢吡喃类化合物，水苏毒素H（1）和水苏菌毒素H（9），以及十一种已知类似物（2 - 8，10 - 13）。通过广泛的核磁共振数据和质谱分析确定了它们的结构。化合物9 - 12对三种人类癌细胞系K562、Hela和HL60显示出较弱的细胞毒性，IC50范围为18.5 - 52.8 μM。
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