McCoy G C, Blanchard E B, Wittrock D A, Morrison S, Pangburn L, Siracusa K, Pallmeyer T P
Albany Medical College, State University of New York.
Biofeedback Self Regul. 1988 Jun;13(2):139-50. doi: 10.1007/BF01001497.
Fifty-two hypertensive patients whose blood pressure (BP) was controlled on two medications received either 16 sessions of thermal biofeedback (n = 30) for hand warming or 8 sessions of progressive muscle relaxation (n = 22) prior to medication withdrawal. A number of biochemical measures, including plasma norepinephrine (NEPI) (supine and standing), plasma renin activity, plasma aldosterone, and urinary sodium and potassium, were taken before treatment and after treatment while medication remained constant. Results for the biofeedback-treated patients showed significant reductions in mean arterial pressure as well as in both supine and standing NEPI, while the other biochemical measures were unchanged. There were no significant changes on any variable for the relaxation-treated patients. Although the group data support a reduction in peripheral sympathetic tone as associated with the decrease in BP for the thermal biofeedback condition, dose-response relations were not significant.
52名高血压患者在服用两种药物后血压得到控制，在停药前，其中30名患者接受了16次手部升温的热生物反馈治疗，22名患者接受了8次渐进性肌肉松弛治疗。在治疗前和治疗后，药物保持不变的情况下，进行了多项生化指标检测，包括血浆去甲肾上腺素（NEPI）（仰卧位和站立位）、血浆肾素活性、血浆醛固酮以及尿钠和尿钾。生物反馈治疗组患者的平均动脉压以及仰卧位和站立位NEPI均显著降低，而其他生化指标未发生变化。接受松弛治疗的患者在任何变量上均无显著变化。尽管组间数据支持热生物反馈治疗条件下外周交感神经张力降低与血压下降相关，但剂量反应关系并不显著。
