Perez-Polo J R, Foreman P J, Jackson G R, Shan D, Taglialatela G, Thorpe L W, Werrbach-Perez K
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
Mol Neurobiol. 1990 Spring-Summer;4(1-2):57-91. doi: 10.1007/BF02935585.
The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant--antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.
神经营养因子神经生长因子（NGF）对神经元细胞死亡的调节作用已在神经发育过程及神经系统损伤后得到描述。此外，据报道，在老龄啮齿动物和人类中，交感神经系统及中枢神经系统（CNS）胆碱能区域中对NGF有反应的老龄神经元的NGF活性降低。尽管对NGF及其受体的分子结构已有一定了解，但对NGF的作用机制却知之甚少。在此，作为对NGF在发育过程中、损伤后及老龄CNS中对神经元存活的已知作用的分子解释的一部分内容，将讨论NGF在调节氧化剂 - 抗氧化剂平衡中的可能作用。
