Aurora Health Care, Department of Pharmacy Services, Milwaukee, Wisconsin, USA
University of Florida College of Pharmacy, Jacksonville, Florida, USA.
Antimicrob Agents Chemother. 2019 Feb 26;63(3). doi: 10.1128/AAC.02211-18. Print 2019 Mar.
We analyzed the impact of vancomycin (VAN) combined with adjuvant β-lactam therapy (Combo) on persistent (≥5 days) methicillin-resistant bacteremia versus VAN alone by using pooled data from two previously published observational studies ( = 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; = 0.062).
我们分析了万古霉素（VAN）联合辅助β-内酰胺治疗（Combo）与万古霉素单药治疗对持续（≥5 天）耐甲氧西林菌血症的影响，使用来自两项先前发表的观察性研究的汇总数据（n=156）。与万古霉素单药治疗相比，联合治疗与持续菌血症呈负相关（调整后的优势比，0.460；95%置信区间，0.229 至 0.923）。联合治疗比万古霉素更常见急性肾损伤（分别为 18.9%和 7.6%；=0.062）。
