β-内酰胺类抗生素联合万古霉素治疗耐甲氧西林金黄色葡萄球菌菌血症：β-内酰胺类抗生素种类重要吗？
Adjuvant β-Lactam Therapy Combined with Vancomycin for Methicillin-Resistant Bacteremia: Does β-Lactam Class Matter?
机构信息
Aurora Health Care, Department of Pharmacy Services, Milwaukee, Wisconsin, USA
University of Florida College of Pharmacy, Jacksonville, Florida, USA.
出版信息
Antimicrob Agents Chemother. 2019 Feb 26;63(3). doi: 10.1128/AAC.02211-18. Print 2019 Mar.
Abstract
We analyzed the impact of vancomycin (VAN) combined with adjuvant β-lactam therapy (Combo) on persistent (≥5 days) methicillin-resistant bacteremia versus VAN alone by using pooled data from two previously published observational studies ( = 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; = 0.062).
摘要
我们分析了万古霉素（VAN）联合辅助β-内酰胺治疗（Combo）与万古霉素单药治疗对持续（≥5 天）耐甲氧西林菌血症的影响，使用来自两项先前发表的观察性研究的汇总数据（n=156）。与万古霉素单药治疗相比，联合治疗与持续菌血症呈负相关（调整后的优势比，0.460；95%置信区间，0.229 至 0.923）。联合治疗比万古霉素更常见急性肾损伤（分别为 18.9%和 7.6%；=0.062）。
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