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Regulation of soluble CD127 protein release and corresponding transcripts expression in T lymphocytes from septic shock patients.

作者信息

Mouillaux Julie, Allam Camille, Rimmelé Thomas, Uberti Thomas, Delwarde Benjamin, Textoris Julien, Monneret Guillaume, Peronnet Estelle, Venet Fabienne

机构信息

EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) » Lyon 1 University / Hospices Civils de Lyon / bioMérieux, 5 place d'Arsonval, 69437, Lyon Cedex 03, France.

Joint Research Unit HCL-bioMérieux-Lyon 1 University, Hôpital Edouard Herriot, 5 place d'Arsonval, 69003, Lyon, France.

出版信息

Intensive Care Med Exp. 2019 Jan 8;7(1):3. doi: 10.1186/s40635-018-0220-3.

DOI:10.1186/s40635-018-0220-3
PMID:30617646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6325048/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/82da9b92d586/40635_2018_220_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/bbd8c0809cc6/40635_2018_220_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/d0cae3cbe72d/40635_2018_220_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/82da9b92d586/40635_2018_220_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/bbd8c0809cc6/40635_2018_220_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/d0cae3cbe72d/40635_2018_220_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/173a/6325048/82da9b92d586/40635_2018_220_Fig3_HTML.jpg

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Intensive Care Med Exp. 2019 Jan 8;7(1):3. doi: 10.1186/s40635-018-0220-3.
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IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.白细胞介素-7(IL-7)与人类免疫缺陷病毒反式激活蛋白(HIV Tat蛋白)协同作用,下调CD8 T细胞上CD127的表达。
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CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients--reversal by highly active anti-retroviral therapy (HAART).HIV感染患者记忆性CD8 T细胞中CD127的表达及调控发生改变——高效抗逆转录病毒疗法(HAART)可使其逆转
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Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients.循环调节性T细胞(CD4(+)CD25(+)CD127(-))数量增加促使脓毒性休克患者出现淋巴细胞无反应性。
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The influence of HIV on CD127 expression and its potential implications for IL-7 therapy.HIV 对 CD127 表达的影响及其对 IL-7 治疗的潜在影响。
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IL-7 induces sCD127 release and mCD127 downregulation in human CD8 T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection.白细胞介素 7(IL-7)通过不同但重叠的机制诱导人 CD8 T 细胞释放可溶性 CD127(sCD127)并下调膜结合 CD127(mCD127),这两种机制在 HIV 感染中均受损。
Eur J Immunol. 2020 Oct;50(10):1537-1549. doi: 10.1002/eji.201948453. Epub 2020 May 27.

本文引用的文献

1
Low Interleukin-7 Receptor Messenger RNA Expression Is Independently Associated With Day 28 Mortality in Septic Shock Patients.低白细胞介素-7 受体信使 RNA 表达与脓毒性休克患者第 28 天死亡率独立相关。
Crit Care Med. 2018 Nov;46(11):1739-1746. doi: 10.1097/CCM.0000000000003281.
2
Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.白细胞介素-7 可恢复脓毒性休克中的淋巴细胞:IRIS-7 随机临床试验。
JCI Insight. 2018 Mar 8;3(5):98960. doi: 10.1172/jci.insight.98960.
3
Elevated soluble IL-7 receptor concentration in non-survivor ICU patients.
非存活的重症监护病房患者可溶性白细胞介素-7受体浓度升高。
Intensive Care Med. 2016 Oct;42(10):1639-1640. doi: 10.1007/s00134-016-4445-x. Epub 2016 Jul 9.
4
Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function.1 型糖尿病中白细胞介素-7 受体 α 可溶性形式的浓度和活性鉴定了高血糖与免疫功能之间的相互作用。
Diabetes. 2013 Jul;62(7):2500-8. doi: 10.2337/db12-1726. Epub 2013 Mar 1.
5
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis.急性脓毒症病程中淋巴细胞表型和功能的前瞻性分析。
Crit Care. 2012 Jun 28;16(3):R112. doi: 10.1186/cc11404.
6
IL-7 in human health and disease.IL-7 在人类健康和疾病中的作用。
Semin Immunol. 2012 Jun;24(3):218-24. doi: 10.1016/j.smim.2012.02.005. Epub 2012 Mar 10.
7
Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.人血浆可溶性白细胞介素-7受体的鉴定及生化特性:HIV-1感染患者中浓度较低
J Immunol. 2009 Jun 15;182(12):7389-97. doi: 10.4049/jimmunol.0900190.
8
The sepsis seesaw: tilting toward immunosuppression.脓毒症的跷跷板:向免疫抑制倾斜。
Nat Med. 2009 May;15(5):496-7. doi: 10.1038/nm0509-496.
9
Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling.IL-7和TCR信号对人IL-7受体α表达的差异调节
J Immunol. 2008 Apr 15;180(8):5201-10. doi: 10.4049/jimmunol.180.8.5201.
10
Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.通过淋巴细胞表型分析区分脓毒症与非脓毒症危重病。
J Am Coll Surg. 2008 Feb;206(2):335-42. doi: 10.1016/j.jamcollsurg.2007.07.038. Epub 2007 Oct 29.