Barros Priscila O, Berthoud Tamara K, Aloufi Nawaf, Angel Jonathan B
Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Immunotargets Ther. 2021 Mar 8;10:47-62. doi: 10.2147/ITT.S264149. eCollection 2021.
Soluble cytokine receptors can influence immune responses by modulating the biological functions of their respective ligands. These effects can be either agonistic or antagonistic and a number of soluble cytokine receptors have been shown to play critical roles in both maintenance of health and disease pathogenesis. Soluble IL-7Ra (sCD127) is one such example. With its impact on the IL-7/CD127 pathway, which is fundamental for the development and homeostasis of T cells, the role of sCD127 in health and disease has been extensively studied in recent years. Within this review, the role of sCD127 in maintaining host immune function is presented. Next, by addressing genetic factors affecting sCD127 expression and the associated levels of sCD127 production, the roles of sCD127 in autoimmune disease, infections and cancer are described. Finally, advances in the field of soluble cytokine therapy and the potential for sCD127 as a biomarker and therapeutic agent are discussed.
可溶性细胞因子受体可通过调节其各自配体的生物学功能来影响免疫反应。这些效应可以是激动性的或拮抗性的，并且许多可溶性细胞因子受体已被证明在维持健康和疾病发病机制中都起着关键作用。可溶性白细胞介素-7受体α（sCD127）就是这样一个例子。鉴于其对白细胞介素-7/CD127通路的影响，而该通路对T细胞的发育和稳态至关重要，近年来sCD127在健康和疾病中的作用已得到广泛研究。在本综述中，阐述了sCD127在维持宿主免疫功能中的作用。接下来，通过探讨影响sCD127表达的遗传因素以及sCD127的相关产生水平，描述了sCD127在自身免疫性疾病、感染和癌症中的作用。最后，讨论了可溶性细胞因子治疗领域的进展以及sCD127作为生物标志物和治疗剂的潜力。
