Berezenko V, Bogdanova T, Krotevich M, Savenko Y, Vankhanova T
O. Bogomolets National Medical University, Department of Pediatrics №1, Kyiv; 2SI "Academician O.M. Lukyanova Institute of pediatrics, obstetrics and gynaecology of NAMS of Ukraine"; 3National Cancer Institute, Kyiv, Ukraine.
Georgian Med News. 2018 Nov(284):93-97.
The aim of our work was to evaluate the morphological features of the mucous membrane of the stomach and duodenum in children with chronic diseases of the gastroduodenal zone on the background of food hypersensitivity. Morphological study was conducted for 50 adolescents aged 12 to 17 years who were in inpatient treatment in the gastroenterology department. In order to verify the diagnosis, all children were checked by fibroesophagogastroduodenoscopy of the upper digestive tract with biopsy of the mucous membrane of the stomach antrum and the descending part of the duodenum. Bioptates were stained by hematoxylin-eosin, Van Gieson and performed on light microscope. The results of the research of the mucous membrane of the stomach and duodenum show that adolescents with chronic gastroduodenitis and food hypersensitivity have 17 times higher risk of developing atrophy of duodenal mucous membrane, 11 times higher frequency of eosinophilic infiltration and 3 times higher incidence of mucous membrane fibrosis in the duodenum.
我们研究的目的是评估在食物过敏背景下患有胃十二指肠区慢性疾病的儿童胃和十二指肠黏膜的形态学特征。对50名年龄在12至17岁、正在胃肠病科住院治疗的青少年进行了形态学研究。为了确诊，所有儿童均接受了上消化道纤维食管胃十二指肠镜检查，并对胃窦和十二指肠降部黏膜进行活检。活检组织用苏木精-伊红、范吉森染色，并在光学显微镜下观察。胃和十二指肠黏膜的研究结果表明，患有慢性胃炎和食物过敏的青少年十二指肠黏膜萎缩风险高17倍，嗜酸性粒细胞浸润频率高11倍，十二指肠黏膜纤维化发生率高3倍。
