塞内加尔凯杜古达菲阴性人群中的无症状感染。
Asymptomatic infections among Duffy-negative population in Kedougou, Senegal.
作者信息
Niang Makhtar, Sane Rokhaya, Sow Abdourahmane, Sadio Bacary D, Chy Sophy, Legrand Eric, Faye Ousmane, Diallo Mawlouth, Sall Amadou A, Menard Didier, Toure-Balde Aissatou
机构信息
1Immunology Unit, Pasteur Institute of Dakar, BP 220 Dakar, Senegal.
2Department of Animal Biology, Cheikh Anta Diop University of Dakar, Dakar, Senegal.
出版信息
Trop Med Health. 2018 Dec 29;46:45. doi: 10.1186/s41182-018-0128-3. eCollection 2018.
BACKGROUND
In the southeastern Senegal, the report of infections among febrile patients in Kedougou constitutes a new emerging health problem.
METHODS
Samples from 48 asymptomatic schoolchildren sampled twice a year over 2 years were used to explore the reservoir of parasite infections in this region. Both Duffy genotyping and species diagnostic assays were performed.
RESULTS
PCR assays detected genomic DNA in 38.5% (74/192) of samples. Pure and infections were identified in 79.7% (59/74) and 20.3% (15/74) of samples, respectively. All schoolchildren were classified as Duffy-negative by genotyping. infections were detected in five children: in two children during both years, in one child in 2010 and on May 2011, and only in 2010 for the remaining two children.
CONCLUSIONS
This unexpectedly high proportion of infections in asymptomatic Duffy-negative children highlights to consider vivax malaria as an emerging problem in Senegal.
背景
在塞内加尔东南部，凯杜古地区发热患者感染情况的报告构成了一个新出现的健康问题。
方法
从48名无症状学童中采集样本，每年采样两次，持续2年，以探索该地区疟原虫感染的储存宿主。进行了达菲基因分型和疟原虫种类诊断检测。
结果
聚合酶链反应（PCR）检测在38.5%（74/192）的样本中检测到疟原虫基因组DNA。在79.7%（59/74）的样本中鉴定出单纯间日疟感染，在20.3%（15/74）的样本中鉴定出混合感染。通过基因分型，所有学童均被归类为达菲阴性。在5名儿童中检测到间日疟感染：2名儿童在两年中均检测到，1名儿童在2010年和2011年5月检测到，其余2名儿童仅在2010年检测到。
结论
无症状达菲阴性儿童中间日疟感染比例出乎意料地高，这凸显了将间日疟视为塞内加尔一个新出现问题的必要性。
Zotero 插件