Madeira Caroline, Alheira Flavio V, Calcia Marilia A, Silva Thuany C S, Tannos Filippe M, Vargas-Lopes Charles, Fisher Melissa, Goldenstein Nelson, Brasil Marco Antonio, Vinogradov Sophia, Ferreira Sergio T, Panizzutti Rogerio
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Serviço de Psiquiatria e Psicologia Médica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Front Psychiatry. 2018 Dec 19;9:713. doi: 10.3389/fpsyt.2018.00713. eCollection 2018.
Converging evidence indicates that dysfunctions in glutamatergic neurotransmission and in the glutamate-glutamine cycle play a role in the pathophysiology of schizophrenia. Here, we investigated glutamate and glutamine levels in the blood of patients with recent onset schizophrenia or chronic schizophrenia compared to healthy controls. Compared with healthy controls, patients with recent onset schizophrenia showed increased glutamine/glutamate ratio, while patients with chronic schizophrenia showed decreased glutamine/glutamate ratio. Results indicate that circulating glutamate and glutamine levels exhibit a dual behavior in schizophrenia, with an increase of glutamine/glutamate ratio at the onset of schizophrenia followed by a decrease with progression of the disorder. Further studies are warranted to elucidate the mechanisms and consequences of changes in circulating glutamate and glutamine in schizophrenia.
越来越多的证据表明，谷氨酸能神经传递和谷氨酸-谷氨酰胺循环功能障碍在精神分裂症的病理生理学中起作用。在此，我们研究了近期发病的精神分裂症患者或慢性精神分裂症患者与健康对照者血液中的谷氨酸和谷氨酰胺水平。与健康对照者相比，近期发病的精神分裂症患者的谷氨酰胺/谷氨酸比值升高，而慢性精神分裂症患者的谷氨酰胺/谷氨酸比值降低。结果表明，精神分裂症患者循环中的谷氨酸和谷氨酰胺水平呈现出双重变化，在精神分裂症发病初期谷氨酰胺/谷氨酸比值升高，随后随着病情进展而降低。有必要进一步研究以阐明精神分裂症患者循环中谷氨酸和谷氨酰胺变化的机制及后果。
