Wu Yichao, Zaiden Norazean, Cao Bin
State Key Laboratory of Agricultural Microbiology, College of Resources and Environment, Huazhong Agricultural University, Wuhan, China.
Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.
Front Microbiol. 2018 Dec 12;9:3096. doi: 10.3389/fmicb.2018.03096. eCollection 2018.
is often reported to be one of the major members of microbial communities in various natural and engineered environments. Versatile catabolic capabilities of have been studied extensively in the last decade. In contrast, little is known about the ecological roles and adaptation of to different environments as well as the virulence of potentially pathogenic strains. In this study, we provide genomic insights into the potential ecological roles and virulence of by analysing the entire gene set (pangenome) and the genes present in all genomes (core genome) using 34 genomes of 11 different species. The analyses revealed that the metabolic pathways enabling to acquire energy from various nutrient sources are well conserved. Genes for denitrification and ammonification are abundant in , suggesting that plays an important role in the nitrogen biogeochemical cycle. They also encode sophisticated redox sensory systems and diverse c-di-GMP controlling systems, allowing them to be able to effectively adjust their biofilm lifestyle to changing environments. The virulence factors in were found to be highly species-specific. The conserved strategies used by potentially pathogenic for surface adherence, motility control, nutrient acquisition and stress tolerance were also revealed.
通常被报道为各种自然和工程环境中微生物群落的主要成员之一。在过去十年中，对其多样的分解代谢能力进行了广泛研究。相比之下，关于其生态作用、对不同环境的适应性以及潜在致病菌株的毒力知之甚少。在本研究中，我们通过使用11种不同物种的34个基因组分析整个基因集（泛基因组）和所有基因组中存在的基因（核心基因组），提供了关于其潜在生态作用和毒力的基因组见解。分析表明，使能够从各种营养源获取能量的代谢途径高度保守。反硝化和氨化基因在中丰富，表明在氮生物地球化学循环中起重要作用。它们还编码复杂的氧化还原传感系统和多样的环二鸟苷酸控制系统，使其能够有效地根据环境变化调整其生物膜生活方式。中发现的毒力因子具有高度的物种特异性。还揭示了潜在致病用于表面黏附、运动控制、营养获取和应激耐受的保守策略。
