California National Primate Research Center, University of California Davis, Davis, California.
Am J Primatol. 2019 Jan;81(1):e22948. doi: 10.1002/ajp.22948. Epub 2019 Jan 8.
Diarrhea with secondary decompensation is the main cause of morbidity and mortality in captive young rhesus macaque (Macaca mulatta) colonies. Approximately 25% of diarrhea cases with secondary decompensation are considered to be idiopathic chronic diarrhea. The purpose of this study was to investigate the suspected but not systematically examined association between rotavirus infection and diarrhea with secondary decompensation among young rhesus macaques at the California National Primate Research Center (CNPRC). Blood and stool samples were collected from 89 randomly selected young animals (age range: 6 months to 1.5 years) and were tested for the presence of rotavirus antibody, and rotavirus antigen, respectively, using enzyme-linked immunosorbent assays (ELISA's). Test and clinical data were analyzed using Fisher's exact tests and multivariate logistic regression model. Our analysis indicates that rotavirus is endemic among young outdoor-housed rhesus macaques at the CNPRC. Although the relationship between detectable rotavirus antigen in stool and symptomatic diarrhea with secondary decompensation was not significant, there was a significant association between rotavirus seropositivity and a history of diarrhea with secondary decompensation within the past 6 months. While our cross-sectional and case-control study suggests an association between rotavirus infection and diarrhea with secondary decompensation among captive rhesus macaques, more extensive longitudinal studies on larger cohorts and with more intensive sample collection are needed to confirm these findings.
继发性失代偿性腹泻是圈养幼年恒河猴（Macaca mulatta）群体发病和死亡的主要原因。约 25%的继发性失代偿性腹泻病例被认为是特发性慢性腹泻。本研究旨在调查加利福尼亚国家灵长类动物研究中心（CNPRC）中，疑似但未系统检查的轮状病毒感染与幼年恒河猴继发性失代偿性腹泻之间的关联。从 89 只随机选择的幼年动物（年龄范围：6 个月至 1.5 岁）中采集血液和粪便样本，分别使用酶联免疫吸附测定（ELISA）检测轮状病毒抗体和轮状病毒抗原。使用 Fisher 精确检验和多变量逻辑回归模型分析测试和临床数据。我们的分析表明，轮状病毒在 CNPRC 的户外饲养幼年恒河猴中流行。虽然粪便中检测到的轮状病毒抗原与继发性失代偿性症状性腹泻之间的关系不显著，但轮状病毒血清阳性与过去 6 个月内继发性失代偿性腹泻史之间存在显著关联。虽然我们的横断面和病例对照研究表明，轮状病毒感染与圈养恒河猴继发性失代偿性腹泻之间存在关联，但需要对更大队列进行更广泛的纵向研究，并进行更密集的样本采集，以证实这些发现。
