Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104, Freiburg im Breisgau, Germany.
Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3392-3397. doi: 10.1002/anie.201813646. Epub 2019 Jan 29.
A rhodium/photoredox dual catalyzed regiodivergent α-allylation of amines is described. As an atom-economic and efficient method, alkynes and allenes are used as allylic electrophile surrogates in this novel protocol. With different reaction conditions, synthetically useful branched or linear homoallylic amines could be synthesized in good to excellent yields and regioselectivity. This straightforward strategy complements the traditional transition-metal catalyzed allylation reactions.
本文描述了一种铑/光氧化还原双催化的胺的区域选择性α-烯丙基化反应。作为一种原子经济性和高效的方法，在这个新的反应方案中，炔烃和丙二烯被用作烯丙基亲电试剂的替代物。通过不同的反应条件，可以以良好到优异的收率和区域选择性合成具有合成用途的支链或直链同型烯丙基胺。这种直接的策略补充了传统的过渡金属催化的烯丙基化反应。
