淋巴结采样对 cN0 大型涎腺腺样囊性癌生存的影响。
Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
出版信息
Head Neck. 2019 Jun;41(6):1903-1907. doi: 10.1002/hed.25628. Epub 2019 Jan 8.
Abstract
BACKGROUND
The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear.
METHODS
Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. The cohort was divided into four groups based on number of lymph nodes (LNs) examined on pathology: 0, 1-8, 9-17, and ≥18 LNs.
RESULTS
The rate of occult nodal metastasis was 9.0%. Number of LNs removed was not associated with survival (Reference, 0 LNs; HR = 0.98, 95% CI 0.73-1.32 for 1-8 LNs; HR = 1.22, 95% CI 0.80-1.88 for 9-17 LNs; HR = 0.94, 95% CI 0.61-1.46 for ≥18 LNs) after adjusting for important covariates.
CONCLUSIONS
LN sampling is not associated with survival in cN0 major salivary gland ACC.
摘要
背景
在大涎腺腺样囊性癌的治疗中，择区性颈清扫术的作用尚不清楚。
方法
从国家癌症中心数据库中回顾性提取数据。本研究队列包括 1504 例 2004 年至 2014 年间接受手术治疗、临床 N0 颈部的大涎腺腺样囊性癌患者。根据病理检查的淋巴结数量（LNs），将队列分为 4 组：0、1-8、9-17 和≥18 LNs。
结果
隐匿性淋巴结转移率为 9.0%。淋巴结切除数目与生存无关（参照，0 个 LNs；HR=0.98，95%CI0.73-1.32 为 1-8 个 LNs；HR=1.22，95%CI0.80-1.88 为 9-17 个 LNs；HR=0.94，95%CI0.61-1.46 为≥18 个 LNs），在调整重要协变量后。
结论
在 cN0 大涎腺腺样囊性癌中，LN 取样与生存无关。
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