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Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis.

作者信息

Nichols Derek, Boyle Theresa A, Noyes David, Latifi Kujtim, Feygelman Vladimir, Jackson Isabel, Vujaskovic Zeljko, Antonia Scott, Perez Bradford A

机构信息

Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

出版信息

J Thorac Dis. 2018 Nov;10(11):6254-6260. doi: 10.21037/jtd.2018.10.01.

DOI:10.21037/jtd.2018.10.01
PMID:30622798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6297393/
Abstract
摘要

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Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.Durvalumab 用于 III 期非小细胞肺癌放化疗后的治疗。
N Engl J Med. 2017 Nov 16;377(20):1919-1929. doi: 10.1056/NEJMoa1709937. Epub 2017 Sep 8.
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Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial.既往放疗与帕博利珠单抗治疗非小细胞肺癌的临床活性及毒性：KEYNOTE-001 1期试验的二次分析
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Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study.卡铂和培美曲塞联合或不联合帕博利珠单抗用于晚期非鳞状非小细胞肺癌：开放标签KEYNOTE-021研究的随机2期队列研究
Lancet Oncol. 2016 Nov;17(11):1497-1508. doi: 10.1016/S1470-2045(16)30498-3. Epub 2016 Oct 10.
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Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer.帕博利珠单抗对比化疗用于 PD-L1 阳性非小细胞肺癌。
N Engl J Med. 2016 Nov 10;375(19):1823-1833. doi: 10.1056/NEJMoa1606774. Epub 2016 Oct 8.
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Incidence of Programmed Cell Death 1 Inhibitor-Related Pneumonitis in Patients With Advanced Cancer: A Systematic Review and Meta-analysis.程序性细胞死亡蛋白 1 抑制剂相关肺炎在晚期癌症患者中的发生率：系统评价和荟萃分析。
JAMA Oncol. 2016 Dec 1;2(12):1607-1616. doi: 10.1001/jamaoncol.2016.2453.
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The safety and efficacy of nivolumab in advanced (metastatic) non-small cell lung cancer.纳武单抗治疗晚期（转移性）非小细胞肺癌的安全性和疗效。
Expert Rev Anticancer Ther. 2016 Sep;16(9):903-10. doi: 10.1080/14737140.2016.1220836. Epub 2016 Aug 22.
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Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.伊匹单抗治疗非小细胞肺癌后根治性放疗和术后放疗的毒性
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Anti-PD-1-Related Pneumonitis during Cancer Immunotherapy.癌症免疫治疗期间与抗程序性死亡蛋白1相关的肺炎
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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.放疗和双重检查点阻断激活癌症中的非冗余免疫机制。
Nature. 2015 Apr 16;520(7547):373-7. doi: 10.1038/nature14292. Epub 2015 Mar 9.