El-Dean Adel M Kamal, Abd-Ella Aly A, Hassanien Reda, El-Sayed Mohamed E A, Zaki Remon M, Abdel-Raheem Shaban A A
Chemistry Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt.
Plant Protection Department, Faculty of Agriculture, Assiut University, 71526, Assiut, Egypt.
Toxicol Rep. 2018 Dec 18;6:100-104. doi: 10.1016/j.toxrep.2018.12.004. eCollection 2019.
Neonicotinoids are the most widely used from all existing pesticides. So, in purpose to discover new pesticides being more effective against the aphid, twelve heterocyclic compounds neonicotinoid analogs have been prepared in a pure state; pyrimidothienotetrahydroisoquinolines and their toxicity as potential insecticidal agents against cowpea Aphid, Koch was screened. Their characterizations by using spectroscopic analyses were performed. The toxicity data exhibited that the 8-chloropyrimidine compound is more toxic about 2-fold than a reference insecticide, acetamiprid. The other screened compounds showed weak to strong toxicological activities against cowpea aphid.
新烟碱类是所有现有农药中使用最广泛的。因此，为了发现对蚜虫更有效的新型农药，已制备出12种纯态的杂环化合物新烟碱类似物；对嘧啶噻吩并四氢异喹啉及其作为针对豇豆蚜（Koch）的潜在杀虫剂的毒性进行了筛选。通过光谱分析对它们进行了表征。毒性数据表明，8-氯嘧啶化合物的毒性比对照杀虫剂啶虫脒高约2倍。其他筛选出的化合物对豇豆蚜表现出弱至强的毒理学活性。
