El-Dean Adel M Kamal, Abd-Ella Aly A, Hassanien Reda, El-Sayed Mohamed E A, A Abdel-Raheem Shaban A
Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt.
Plant Protection Department, Faculty of Agriculture, Assiut University, 71526 Assiut, Egypt.
ACS Omega. 2019 May 13;4(5):8406-8412. doi: 10.1021/acsomega.9b00932. eCollection 2019 May 31.
A lot of insecticides are found nowadays, but neonicotinoids are considered the most famous. So, a series of pyridine derivatives neonicotinoids analogues, namely, 3-cyano-4,6-dimethylpyridine-2(1)-one (), 2-chloro-3-cyano-4,6-dimethylpyridine (), 3-cyano-4,6-dimethylpyridine-2(1)-thione (), 3-cyano-4,6-distyrylpyridine-2(1)-thione (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--phenylacetamide (), 3-amino--phenyl-4,6-distyrylthieno[2,3-]pyridine-2-carboxamide (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--(-tolyl)acetamide (), 3-amino-4,6-distyryl--(-tolyl)thieno[2,3-]pyridine-2-carboxamide (), 2-((3-cyano-4,6-distyrylpyridin-2-yl)thio)--(4-methoxyphenyl)acetamide (), and 3-amino--(4-methoxyphenyl)-4,6-distyrylthieno[2,3-]pyridine-2-carboxamide (), have been designed and synthesized in pure state, and their agricultural bioefficacy as insecticides against cowpea aphid Koch was screened. The structures of the synthesized compounds were verified by means of spectroscopic and elemental analyses. Insecticidal bioefficacy data illustrated that some compounds are excellent against cowpea aphid, and the bioefficacy of the rest of the tested compounds ranged from good to moderate against the same insects.
如今发现了许多杀虫剂，但新烟碱类被认为是最著名的。因此，设计并合成了一系列吡啶衍生物新烟碱类似物，即3-氰基-4,6-二甲基吡啶-2(1)-酮（）、2-氯-3-氰基-4,6-二甲基吡啶（）、3-氰基-4,6-二甲基吡啶-2(1)-硫酮（）、3-氰基-4,6-二苯乙烯基吡啶-2(1)-硫酮（）、2-((3-氰基-4,6-二苯乙烯基吡啶-2-基)硫代)-α-苯基乙酰胺（）、3-氨基-α-苯基-4,6-二苯乙烯基噻吩并[2,3-b]吡啶-2-甲酰胺（）、2-((3-氰基-4,6-二苯乙烯基吡啶-2-基)硫代)-α-(对甲苯基)乙酰胺（）、3-氨基-4,6-二苯乙烯基-α-(对甲苯基)噻吩并[2,3-b]吡啶-2-甲酰胺（）、2-((3-氰基-4,6-二苯乙烯基吡啶-2-基)硫代)-α-(4-甲氧基苯基)乙酰胺（）以及3-氨基-α-(4-甲氧基苯基)-4,6-二苯乙烯基噻吩并[2,3-b]吡啶-2-甲酰胺（），并以纯态合成，同时筛选了它们作为杀虫剂对豇豆蚜（豆蚜）的农业生物活性。通过光谱和元素分析对合成化合物的结构进行了验证。杀虫生物活性数据表明，一些化合物对豇豆蚜具有优异的活性，其余测试化合物对相同昆虫的生物活性范围从良好到中等。
