Kizildağ Alper, Çiçek Yasin, Arabaci Taner, Köse Oğuz
a Department of Periodontology, Faculty of Dentistry , Pamukkale University , Denizli , Turkey.
b Department of Periodontology, Faculty of Dentistry , Adıyaman University , Adıyaman , Turkey.
Growth Factors. 2018 Dec;36(5-6):239-245. doi: 10.1080/08977194.2018.1551217. Epub 2019 Jan 9.
The present study evaluates the effects of leukocyte-platelet-rich fibrin (L-PRF) combined with open flap debridement (OFD) on clinical parameters and growth factors levels (GFL) in chronic periodontitis (CP) patients. This trial was registered at clinicaltrials.gov as NCT02594605. 16 patients (32 sites) with chronic periodontitis who had at least two areas of horizontal bone loss, were treated with OFD alone or L-PRF with OFD (OFD + L-PRF). GFL in gingival crevicular fluid (GCF) were analyzed at baseline, 1 week, 2 weeks and 4 weeks after operation. Probing depth (PD) and clinical attachment level (CAL) were measured at baseline and 6 months postoperatively. PD reduction and CAL gain were significantly higher in the OFD + L-PRF sites than in OFD sites. OFD + L-PRF group showed significantly increased bone morphogenetic protein-2 and insulin-like growth factor-1 at 2 weeks compared with baseline. L-PRF combined with OFD significantly increases GFL and thus, it enhances the periodontal healing on CP patients.
本研究评估富白细胞血小板纤维蛋白（L-PRF）联合开放式翻瓣清创术（OFD）对慢性牙周炎（CP）患者临床参数和生长因子水平（GFL）的影响。该试验已在clinicaltrials.gov注册，注册号为NCT02594605。16例患有慢性牙周炎且至少有两个水平骨丧失区域的患者（32个位点），分别接受单纯OFD治疗或OFD联合L-PRF治疗（OFD + L-PRF）。在基线、术后1周、2周和4周分析龈沟液（GCF）中的GFL。在基线和术后6个月测量探诊深度（PD）和临床附着水平（CAL）。OFD + L-PRF位点的PD降低和CAL增加显著高于OFD位点。与基线相比，OFD + L-PRF组在术后2周时骨形态发生蛋白-2和胰岛素样生长因子-1显著增加。L-PRF联合OFD可显著提高GFL，从而促进CP患者的牙周愈合。
