Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain.
Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 329, Kingdom of Bahrain.
Int J Environ Res Public Health. 2019 Jan 8;16(1):148. doi: 10.3390/ijerph16010148.
Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe use of AgNPs could pose a real threat, not only to public health but also to economic growth in many industries. In this paper, we tested the effect of AgNPs on memory, learning, social behaviour and motor function of BALB/C mice. Outcomes of the present study suggested an impairment of these functions in AgNPs treated groups. Overall, obtained data support the evidence that the systemic exposure to AgNPs may result in alteration of the cerebral cognition and warrants further consideration on the impact of the AgNPs on human health with respect to their potential neurotoxicity.
纳米技术的代表——银纳米粒子（AgNPs），由于其杀菌特性，出现在各种日常产品中，如水过滤器、打印机墨水、牙膏、食品包装和化妆品。鉴于公众接触的水平如此之高，AgNPs 的安全性从未得到充分证实。AgNPs 的不安全使用不仅对公共健康构成威胁，而且对许多行业的经济增长构成威胁。在本文中，我们测试了 AgNPs 对 BALB/C 小鼠记忆、学习、社交行为和运动功能的影响。本研究的结果表明，AgNPs 处理组的这些功能受损。总的来说，获得的数据支持了这样的证据，即全身暴露于 AgNPs 可能导致大脑认知功能的改变，需要进一步考虑 AgNPs 对人类健康的影响，特别是它们的潜在神经毒性。
