Nakagawa Taisuke, Doi Akihiro, Ohno Koichi, Yokoyama Nozomu, Tsujimoto Hajime
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2019 Mar 14;81(3):348-352. doi: 10.1292/jvms.18-0493. Epub 2019 Jan 10.
Megaesophagus (ME) is a common esophageal disease in dogs and the prognosis is generally poor, especially with aspiration pneumonia (AP). We retrospectively investigated the clinical features and prognosis of canine ME in Japan. Twenty-eight dogs were included in this study, with the Miniature Dachshund breed being significantly overrepresented (odds ratio: 4.33). Most cases (21 of 28) were diagnosed as idiopathic ME and Myasthenia gravis was the most common cause of secondary ME. The overall median survival time (MST) was not reached and the 3-month survival rate was 85.7%. Ten dogs were diagnosed with AP, at least once during the study period, and the MST of ME dogs with AP was 114 days. The survival time overall and even with AP, was notably more prolonged compared to the previous studies. We hypothesized that treatment for canine ME could prolong the survival time, even in those with both ME and AP.
巨食管症（ME）是犬类常见的食管疾病，其预后通常较差，尤其是合并吸入性肺炎（AP）时。我们回顾性研究了日本犬类ME的临床特征和预后。本研究纳入了28只犬，其中迷你腊肠犬品种的比例显著过高（优势比：4.33）。大多数病例（28例中的21例）被诊断为特发性ME，重症肌无力是继发性ME最常见的原因。总体中位生存时间（MST）未达到，3个月生存率为85.7%。10只犬在研究期间至少被诊断出一次AP，合并AP的ME犬的MST为114天。与之前的研究相比，总体生存时间以及合并AP时的生存时间都显著延长。我们推测，犬类ME的治疗可以延长生存时间，即使是对于同时患有ME和AP的犬。
