McBrearty Alix R, Ramsey Ian K, Courcier Emily A, Mellor Dominic J, Bell Rory
Division of Companion Animal Sciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G61 1QH, Scotland.
J Am Vet Med Assoc. 2011 Jun 15;238(12):1622-8. doi: 10.2460/javma.238.12.1622.
To investigate the association of 6 clinical features with outcome of dogs with generalized megaesophagus.
Retrospective cohort study.
71 client-owned dogs with radiographic evidence of generalized esophageal dilation.
Medical records were reviewed for data on signalment, age at onset of clinical signs, body weight, evidence of undernutrition, and the administration of drugs to treat or prevent esophagitis. Radiographs were reviewed for evidence of aspiration pneumonia (AP) and to calculate the relative esophageal diameter. Details of outcome were collected from the medical records and by contacting owners and referring veterinarians. The association of 6 factors with death before discharge and overall survival time was assessed.
Overall median survival time was 90 days. Nineteen (26.7%) patients died before discharge from the hospital. Radiographic evidence of AP was both positively associated with death before discharge and negatively associated with overall survival time. An age at onset of clinical signs of >13 months was negatively associated with overall survival time. No evidence of an association of the degree of esophageal dilation or the use of drugs to prevent or treat esophagitis with death before discharge or overall survival time was found.
Radiographic evidence of AP and the age at onset of clinical signs were the only variables found to be significantly associated with survival time in this study, and this should be considered when advising on prognosis in dogs with megaesophagus.
探讨6项临床特征与全身性巨食管症犬预后的相关性。
回顾性队列研究。
71只客户拥有的犬，有全身性食管扩张的放射学证据。
查阅病历，获取有关特征、临床症状出现时的年龄、体重、营养不良证据以及治疗或预防食管炎药物使用情况的数据。复查X光片，以获取吸入性肺炎（AP）的证据并计算相对食管直径。从病历以及通过联系主人和转诊兽医收集预后详情。评估6项因素与出院前死亡及总生存时间的相关性。
总中位生存时间为90天。19只（26.7%）病犬在出院前死亡。AP的放射学证据与出院前死亡呈正相关，与总生存时间呈负相关。临床症状出现时年龄>13个月与总生存时间呈负相关。未发现食管扩张程度或预防或治疗食管炎药物的使用与出院前死亡或总生存时间存在相关性的证据。
在本研究中，AP的放射学证据和临床症状出现时的年龄是仅有的与生存时间显著相关的变量，在对巨食管症犬的预后提供建议时应予以考虑。
