Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi'an Jiaotong University College of Stomatology, 98 West 5th Road, Xi'an, Shaanxi 710004, China.
Department of Oral and Maxillofacial Surgery, Xi'an Jiaotong University College of Stomatology, 98 West 5th Road, Xi'an, Shaanxi 710004, China.
Biomed Res Int. 2018 Oct 10;2018:5406973. doi: 10.1155/2018/5406973. eCollection 2018.
Visceral pain, a common characteristic of multiple diseases relative to viscera, impacts millions of people worldwide. Although hundreds of studies have explored mechanisms underlying visceral pain, it is still poorly managed. Over the past decade, strong evidence emerged suggesting that microRNAs (miRNAs) play a significant role in visceral nociception through altering neurotransmitters, receptors and other genes at the posttranscriptional level. Under pathological conditions, one kind of miRNA may have several target mRNAs and several kinds of miRNAs may act on one target, suggesting complex interactions and mechanisms between miRNAs and target genes lead to pathological states. In this review we report on recent progress in examining miRNAs responsible for visceral sensitization and provide miRNA-based therapeutic targets for the management of visceral pain.
内脏痛是多种内脏相关疾病的共同特征，影响着全球数百万人。尽管已有数百项研究探索了内脏痛的发生机制，但目前对此仍缺乏有效管理。在过去十年中，大量证据表明 microRNAs（miRNAs）通过在转录后水平改变神经递质、受体和其他基因，在内脏痛觉感受中发挥重要作用。在病理条件下，一种 miRNA 可能有几个靶 mRNA，几种 miRNA 可能作用于一个靶标，这表明 miRNA 和靶基因之间存在复杂的相互作用和机制，导致病理状态。本综述报告了最近在研究导致内脏致敏的 miRNAs 方面的进展，并为内脏痛的管理提供了基于 miRNA 的治疗靶点。
