描绘物理肿瘤微环境与药物传递
Mapping Physical Tumor Microenvironment and Drug Delivery.
机构信息
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
出版信息
Clin Cancer Res. 2019 Apr 1;25(7):2024-2026. doi: 10.1158/1078-0432.CCR-18-3724. Epub 2019 Jan 10.
Abstract
The physical microenvironment of pancreatic tumors is highly abnormal, and this causes significant challenges for drug delivery through multiple mechanisms. Measurements of tissue elasticity could be used as a physical biomarker to assess aberrant drug delivery, and potentially guide stroma-targeting treatment strategies and patient stratification..
摘要
胰腺肿瘤的物理微环境高度异常，这通过多种机制给药物输送带来了重大挑战。组织弹性测量可以作为物理生物标志物，用于评估异常的药物输送，并有可能指导针对基质的治疗策略和患者分层。
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