Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Science. 2019 Jan 11;363(6423):168-173. doi: 10.1126/science.aav0502.
When and how hippocampal neuronal ensembles first organize to support encoding and consolidation of memory episodes, a critical cognitive function of the brain, are unknown. We recorded electrophysiological activity from large ensembles of hippocampal neurons starting on the first day after eye opening as naïve rats navigated linear environments and slept. We found a gradual age-dependent, navigational experience-independent assembly of preconfigured trajectory-like sequences from persistent, location-depicting ensembles during postnatal week 3. Adult-like compressed binding of adjacent locations into trajectories during navigation and their navigational experience-dependent replay during sleep emerged in concert from spontaneous preconfigured sequences only during early postnatal week 4. Our findings reveal ethologically relevant distinct phases in the development of hippocampal preconfigured and experience-dependent sequential patterns thought to be important for episodic memory formation.
当以及如何海马体神经元集合首先组织起来支持记忆情节的编码和巩固，这是大脑的一项关键认知功能，目前尚不清楚。我们记录了从睁眼后第一天开始的大量海马体神经元电生理活动，此时新生大鼠在线性环境中导航并睡眠。我们发现，在出生后第 3 周，持续的、位置描述的神经元集合中，逐渐出现了依赖年龄、与导航经验无关的预设轨迹样序列的组装。在导航过程中，相邻位置的成人样压缩绑定到轨迹中，以及在睡眠期间的导航经验依赖性重放，仅在出生后第 4 周的早期，从自发的预设序列中同时出现。我们的发现揭示了海马体预设和经验依赖的序列模式发展中的两个不同阶段，这些模式被认为对情景记忆的形成很重要。
