Khoury Tawfik, Mahamid Mahmud, Lubany Ahmad, Safadi Mohammad, Farah Amir, Sbeit Wisam, Mari Amir
Gastroenterology and endoscopy united, The Nazareth Hospital, EMMS, Nazareth, Israel.
Faculty of medicine, Bar-Ilan University, Ramat Gan, Israel.
J Gastrointest Cancer. 2020 Mar;51(1):48-52. doi: 10.1007/s12029-019-00202-3.
The aim of the present study was to determine the prevalence of underlying colorectal carcinoma (CRC) in a cohort of patients who experienced an episode of acute diverticulitis and to assess clinical and laboratory parameters that suggest CRC diagnosis.
We performed a single center retrospective study in EMMS Nazareth Hospital from April 2014 to April 2018. All Patients who experienced an episode of acute diverticulitis and underwent a colonoscopy up to 6-month period were included in the study.
Two hundred twenty-five patients (225) patients were included. The mean age was 55.73 ± 13.81 (24-93). One hundred thirty-nine (139) patients were males. Underlying CRC was diagnosed in 2 out of 225 (0.89%) patients and colonic polyps were found in 17 out of 225 patients (7.56%). The average time interval between the episode of diverticulitis and the performance of colonoscopy was 6 weeks. Male gender was significantly associated with CRC and polyp findings (P = 0.039). Moreover, platelet count (353,000 vs. 234,000, P = 0.002) and platelet to lymphocyte ratio (223.65 vs. 127.4, P = 0.015) showed statistically significant correlation with CRC as compared to colonic polyps.
The rate of underlying CRC diagnosis was extremely low after an episode of acute diverticulitis. Male gender and platelet to lymphocyte ratio were predictors for the presence of underlying CRC.
本研究旨在确定经历急性憩室炎发作的患者队列中潜在结直肠癌（CRC）的患病率，并评估提示CRC诊断的临床和实验室参数。
我们于2014年4月至2018年4月在EMMS拿撒勒医院进行了一项单中心回顾性研究。所有经历急性憩室炎发作并在6个月内接受结肠镜检查的患者均纳入研究。
共纳入225例患者。平均年龄为55.73±13.81岁（24 - 93岁）。其中139例为男性。225例患者中有2例（0.89%）被诊断为潜在CRC，225例患者中有17例（7.56%）发现结肠息肉。憩室炎发作与结肠镜检查之间的平均时间间隔为6周。男性与CRC和息肉发现显著相关（P = 0.039）。此外，与结肠息肉相比，血小板计数（353,000对234,000，P = 0.002）和血小板与淋巴细胞比率（223.65对127.4，P = 0.015）与CRC显示出统计学上的显著相关性。
急性憩室炎发作后潜在CRC的诊断率极低。男性和血小板与淋巴细胞比率是潜在CRC存在的预测指标。
