Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany.
Expert Opin Pharmacother. 2011 Jun;12(8):1233-47. doi: 10.1517/14656566.2011.553192. Epub 2011 Feb 28.
Acne is a chronic skin disorder of the pilosebaceous unit; it has a multifactorial pathogenesis. Propionibacterium acnes within the follicle is considered to be a triggering factor of inflammation in acne. Antibiotics have been the primary treatment against P. acnes for more than 40 years. However, a gradual increase in the prevalence of antibiotic-resistant strains of P. acnes has been observed.
This review discusses the pathophysiology of antibiotic-resistant acne development. It focuses on strategies to minimize the development of resistance and, most importantly, confront the development of antibiotic-resistant acne. The literature search was conducted up to August 2010, using the search terms 'acne', 'antibiotic-resistant acne' and 'bacterial resistance'.
Antibiotic-resistant acne is a real phenomenon. Strategies to prevent and confront it should include not only the use of certain treatment regimens but also rational prescribing policies, combination therapies, use of antibacterial non-antibiotic agents and treatment options targeting all the pathogenetic components of acne. Benzoyl-peroxide-based treatment is the most evidence-based approach. Oral isotretinoin remains the most efficacious option for severe acne.
痤疮是一种毛囊皮脂腺单位的慢性皮肤疾病，具有多因素发病机制。痤疮内的痤疮丙酸杆菌被认为是痤疮炎症的触发因素。抗生素作为治疗痤疮丙酸杆菌的主要药物已经有 40 多年的历史了。然而，我们观察到痤疮丙酸杆菌对抗生素的耐药性逐渐增加。
本文讨论了抗生素耐药性痤疮发展的病理生理学。它侧重于最大限度地减少耐药性发展的策略，最重要的是对抗抗生素耐药性痤疮的发展。文献检索截至 2010 年 8 月，使用的检索词是“痤疮”、“抗生素耐药性痤疮”和“细菌耐药性”。
抗生素耐药性痤疮是一个真实存在的现象。预防和对抗它的策略不仅应包括使用某些治疗方案，还应包括合理的处方政策、联合治疗、使用抗菌非抗生素药物以及针对痤疮所有发病机制成分的治疗选择。基于过氧化苯甲酰的治疗是最有循证医学依据的方法。口服异维 A 酸仍然是治疗重度痤疮最有效的选择。
