a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , Hunan , China.
Gynecol Endocrinol. 2019 Jul;35(7):571-575. doi: 10.1080/09513590.2018.1554034. Epub 2019 Jan 11.
This study aimed to compare the levels of interleukin (IL)-1β, IL-6, IL-10, and IL-37 in the serum and peritoneal fluid of women with and without endometriosis. In addition, it aimed to determine the diagnostic values of the cytokines with significantly different concentrations. The levels of IL-1β, IL-6, IL-10, and IL-37 in the serum and peritoneal fluid samples of 40 women with endometriosis and 32 women without endometriosis were measured using an enzyme-linked immunosorbent assay. The serum and peritoneal fluid levels of IL-1β and IL-10 were not statistically significantly different between the endometriosis and control groups. The IL-6 and IL-37 levels in the serum and peritoneal fluid were higher in the endometriosis group than in the control group, and they were correlated with the stage of endometriosis. The AUC for the IL-37 was 0.897 for the serum and 0.934 for the peritoneal fluid, while the AUC for the IL-6 was 0.905 for the serum and 0.952 for the peritoneal fluid. Our results suggest that the serum and peritoneal fluid IL-6 and IL-37 levels were significantly increased in the endometriosis patients, indicating that these cytokines may serve as biomarkers for the diagnosis of endometriosis.
本研究旨在比较子宫内膜异位症患者和无子宫内膜异位症患者血清和腹腔液中白细胞介素 (IL)-1β、IL-6、IL-10 和 IL-37 的水平，并确定具有显著差异浓度的细胞因子的诊断价值。采用酶联免疫吸附试验测定 40 例子宫内膜异位症患者和 32 例无子宫内膜异位症患者血清和腹腔液样本中 IL-1β、IL-6、IL-10 和 IL-37 的水平。子宫内膜异位症组和对照组血清和腹腔液中 IL-1β 和 IL-10 水平无统计学差异。子宫内膜异位症组血清和腹腔液中 IL-6 和 IL-37 水平高于对照组，且与子宫内膜异位症分期相关。血清中 IL-37 的 AUC 为 0.897，腹腔液中为 0.934，而血清中 IL-6 的 AUC 为 0.905，腹腔液中为 0.952。我们的结果表明，子宫内膜异位症患者血清和腹腔液中 IL-6 和 IL-37 水平显著升高，表明这些细胞因子可能作为子宫内膜异位症诊断的生物标志物。
