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本文引用的文献

1
The interleukin-1 family: back to the future.白细胞介素-1 家族：回到未来。
Immunity. 2013 Dec 12;39(6):1003-18. doi: 10.1016/j.immuni.2013.11.010.
2
The interleukin-1 receptor family.白细胞介素-1 受体家族。
Semin Immunol. 2013 Dec 15;25(6):394-407. doi: 10.1016/j.smim.2013.10.023. Epub 2013 Nov 15.
3
Negative regulatory receptors of the IL-1 family.白细胞介素-1 家族的负调控受体。
Semin Immunol. 2013 Dec 15;25(6):408-15. doi: 10.1016/j.smim.2013.10.019. Epub 2013 Nov 14.
4
Imbalance in cytokines from interleukin-1 family - role in pathogenesis of endometriosis.白细胞介素-1 家族细胞因子失衡在子宫内膜异位症发病机制中的作用。
Am J Reprod Immunol. 2012 Aug;68(2):138-45. doi: 10.1111/j.1600-0897.2012.01147.x. Epub 2012 Apr 26.
5
Structure of the activating IL-1 receptor signaling complex.IL-1 受体激活信号复合物的结构。
Nat Struct Mol Biol. 2012 Mar 18;19(4):455-7. doi: 10.1038/nsmb.2260.
6
Peritoneal endometriosis is an inflammatory disease.腹膜子宫内膜异位症是一种炎症性疾病。
Front Biosci (Elite Ed). 2012 Jan 1;4(1):23-40. doi: 10.2741/e358.
7
Endometrial seedlings. A survival instinct? Immunomodulation and its role in the pathophysiology of endometriosis.子宫内膜“幼苗”。一种生存本能？免疫调节及其在子宫内膜异位症病理生理学中的作用。
Minerva Ginecol. 2011 Dec;63(6):563-70.
8
The human P2X7 receptor and its role in innate immunity.人类P2X7受体及其在天然免疫中的作用。
Tissue Antigens. 2011 Nov;78(5):321-32. doi: 10.1111/j.1399-0039.2011.01780.x.
9
The IL-1 family: regulators of immunity.IL-1 家族：免疫调节因子。
Nat Rev Immunol. 2010 Feb;10(2):89-102. doi: 10.1038/nri2691. Epub 2010 Jan 18.
10
Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study.与成熟白细胞介素-1β（IL-1β）相比，前白细胞介素-1β共享一个稳定的核心区域，同时保持明显不同的构象格局：一项氢/氘交换质谱比较研究。
J Biol Chem. 2009 Sep 18;284(38):26137-48. doi: 10.1074/jbc.M109.027375. Epub 2009 Jul 10.

白细胞介素-1β前体与腹膜炎症的关联——在子宫内膜异位症发病机制中的作用

Association of the Precursor of Interleukin-1β and Peritoneal Inflammation-Role in Pathogenesis of Endometriosis.

作者信息

Sikora Justyna, Mielczarek-Palacz Aleksandra, Kondera-Anasz Zdzisława

机构信息

Department of Immunology and Serology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland.

出版信息

J Clin Lab Anal. 2016 Nov;30(6):831-837. doi: 10.1002/jcla.21944. Epub 2016 Mar 28.

DOI:10.1002/jcla.21944
PMID:27018977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6807114/
Abstract

BACKGROUND

The most important proinflammatory cytokine is interleukin (IL)-1β, however its precursor, prointerleukin-1β (proIL-1β), can also potentiate inflammatory state. The aim of this study was to explore the involvement of proIL-1β in pathogenesis of endometriosis. For this purpose, we evaluated concentrations of proIL-1β, IL-1β, and soluble IL-1 receptor type 2 (sIL-1R2) in peritoneal fluid (PF) and macrophage culture medium of women with endometriosis.

METHODS

PF from 55 women with and without endometriosis was collected during laparoscopy. Peritoneal macrophages were cultured in basal and stimulated with lipopolysaccharide (LPS) conditions. Concentrations of cytokines were measured with enzyme-linked immunosorbent assays (ELISA).

RESULTS

PF proIL-1β and IL-1β levels in endometriosis women were higher than in the control. Higher basal and stimulated macrophage secretion of cytokines in endometriosis patients than in the control was observed. However, in endometriosis, there was a higher level of proIL-1β than for the mature molecule. Additionally, lower PF and macrophages culture medium sIL-1R2 levels were observed in women with endometriosis.

CONCLUSIONS

Abnormal proIL-1β concentration in PF and higher macrophage secretion can escalate peritoneal inflammation and endometriosis formation. The results are presented as a total IL-1β, which is a sum of proIL-1β  and IL-1β, and we believe that it reflects the actual cytokine production. The imbalance among all studied cytokines in endometriosis may be linked with an ability to transform acute inflammation to the chronic inflammation.

摘要

背景

最重要的促炎细胞因子是白细胞介素（IL）-1β，然而其前体，即前白细胞介素-1β（proIL-1β），也可增强炎症状态。本研究的目的是探讨proIL-1β在子宫内膜异位症发病机制中的作用。为此，我们评估了子宫内膜异位症患者腹腔液（PF）和巨噬细胞培养基中proIL-1β、IL-1β和可溶性白细胞介素-1受体2型（sIL-1R2）的浓度。

方法

在腹腔镜检查期间收集了55名有或无子宫内膜异位症女性的PF。将腹腔巨噬细胞在基础条件下培养，并用脂多糖（LPS）刺激。采用酶联免疫吸附测定（ELISA）法测定细胞因子浓度。

结果

子宫内膜异位症女性的PF中proIL-1β和IL-1β水平高于对照组。观察到子宫内膜异位症患者基础状态下和受刺激的巨噬细胞分泌的细胞因子水平高于对照组。然而，在子宫内膜异位症中，proIL-1β的水平高于成熟分子。此外，观察到子宫内膜异位症女性的PF和巨噬细胞培养基中sIL-1R2水平较低。

结论

PF中proIL-1β浓度异常和巨噬细胞分泌增加可加剧腹腔炎症和子宫内膜异位症的形成。结果以总IL-1β表示，它是proIL-1β和IL-1β的总和，我们认为它反映了实际的细胞因子产生情况。子宫内膜异位症中所有研究的细胞因子之间的失衡可能与将急性炎症转变为慢性炎症的能力有关。