Xiao Xiao, Zhang Jiayuan, Jin Yuxia, Wang Yunxia, Zhang Qi
Chengdu university of traditional Chinese medicine, Chengdu, Sichuan province, China.
Medicine (Baltimore). 2019 Jan;98(2):e14073. doi: 10.1097/MD.0000000000014073.
Depression is one of common disease in the female perimenopausal period. It deprives women of their right to work and live normally, and even destroys the happiness of their families. Acupuncture is a promising treatment for perimenopausal depression.
Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, China National Knowledge Internet (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and on-line trial registries such as ClinicalTrials.gov (ClinicalTrials.gov/), European Medicines Agency (EMA)(www.ema.europa.eu/ema/), WHO International Clinical Trials Registry Platform (www.who.int/ictrp) will be searched from establishment of the database until Oct. 2018. There are no restrictions on the language of publication. The randomized controlled trials of acupuncture (electroacupuncture and manual acupuncture) for perimenopausal depression will be included, and all articles will be screened and collected by 2 reviewers independently. Revman 5.3.5 software will be used for meta-analysis. The specific process will refer to the Cochrane Handbook for Systematic Review.
The efficacy and safety of acupuncture for perimenopausal depression will be comprehensively assessed from the outcomes, including the effective rate, HAMD score, estrogen level and incidence of adverse events.
This systematic review will provide evidence for whether acupuncture can improve perimenopausal depression.
There is no requirement of ethical approval, and the review will be reported in a peer-reviewed journal.
抑郁症是女性围绝经期的常见疾病之一。它剥夺了女性正常工作和生活的权利，甚至破坏家庭幸福。针灸是治疗围绝经期抑郁症的一种有前景的疗法。
检索Cochrane对照试验中心注册库（CENTRAL）、PubMed、EMBASE、中国知网（CNKI）、重庆维普（CQVIP）、万方数据以及ClinicalTrials.gov（ClinicalTrials.gov/）、欧洲药品管理局（EMA）（www.ema.europa.eu/ema/）、世界卫生组织国际临床试验注册平台（www.who.int/ictrp）等在线试验注册库，检索时间从各数据库建库至2018年10月。对发表语言无限制。纳入针灸（电针和手针）治疗围绝经期抑郁症的随机对照试验，所有文章由2名评价员独立进行筛选和收集。采用Revman 5.3.5软件进行Meta分析。具体过程参考Cochrane系统评价手册。
从有效率、汉密尔顿抑郁量表（HAMD）评分、雌激素水平及不良事件发生率等结局指标全面评估针灸治疗围绝经期抑郁症的疗效和安全性。
本系统评价将为针灸能否改善围绝经期抑郁症提供证据。
无需伦理批准，本评价将在同行评审期刊上发表。
