Department of Trauma and Hand Surgery, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
PLoS One. 2019 Jan 11;14(1):e0209833. doi: 10.1371/journal.pone.0209833. eCollection 2019.
Dupuytren's contracture is a fibroproliferative disorder affecting the palmar fascia of the hand. Most affected are the ring fingers, and little fingers of middle-aged men. Symptomatic for this disease is the increased proliferation and differentiation of fibroblasts to myofibroblasts, which is accompanied by an elevated α-SMA expression. The present study evaluated the therapeutic benefit of blue light (λ = 453 nm, 38 mW/cm2, continuous radiance, spot size 10-12 cm2) as well as the molecular mechanism mediating this effect. It could be determined that blue light significantly diminished the induced α-SMA protein expression in both normal palmar fibroblasts and Duypuytren's fibroblasts. The beneficial effect mediated by this irradiance, radiant exposure and wavelength was associated with an elevated reactive oxygen species generation. Furthermore, the data underlines the potential usefulness of blue light irradiation as a promising therapy option for Dupuytren's disease, especially for relapse prevention, and may represent a useful strategy to treat further fibrotic diseases, such as keloids, hypertrophic scarring, and scleroderma.
掌腱膜挛缩症是一种影响手部掌筋膜的纤维增生性疾病。受影响最严重的是中年男性的无名指和小指。这种疾病的症状是成纤维细胞向肌成纤维细胞的过度增殖和分化，伴随着 α-SMA 表达的升高。本研究评估了蓝光（λ=453nm，38mW/cm2，连续辐射，光斑尺寸 10-12cm2）的治疗益处以及介导这种效应的分子机制。可以确定，蓝光显著降低了正常掌侧成纤维细胞和掌腱膜挛缩症成纤维细胞中诱导的 α-SMA 蛋白表达。这种辐照度、辐射暴露和波长介导的有益效果与活性氧的产生增加有关。此外，这些数据强调了蓝光照射作为治疗掌腱膜挛缩症的一种很有前途的治疗选择的潜力，特别是在预防复发方面，并且可能代表了一种治疗其他纤维性疾病的有用策略，如瘢痕疙瘩、肥厚性瘢痕和硬皮病。
