Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Eur J Pharmacol. 2019 Mar 15;847:1-10. doi: 10.1016/j.ejphar.2019.01.001. Epub 2019 Jan 8.
Randomized controlled trials (RCTs) have demonstrated that alpha lipoic acid (ALA) may change lipid profile, but their results are contradictory. The aim of this study is to conduct a meta-analysis to assess the effects of ALA on lipid profile. Electronic databases including ISI web of science, Ovid, PubMed/Medline, SCOPUS, and Google Scholar were searched up to February 2018. RCTs which assessed ALA effects on lipid profile were selected. Weighted mean difference (WMD) and 95% confidence intervals (CIs) in serum lipids concentrations were defined as intervention effects. Random effects model was used to estimate the pooled effect. Heterogeneity was measured by using I test. The protocol was registered with PROSPERO (No. CRD42017072365). Database search retrieved 12 articles. Serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-) levels were significantly lower in subjects supplemented with alpha-lipoic acid compared with controls (WMD=-10.18 mg/dL; 95% CI: -16.16, -4.20 mg/dL; P = 0.001 and WMD=-9.22 mg/dL; 95% CI: -18.28, -0.16 mg/dL; P = 0.001, respectively), but no significant changes were found for high density lipoprotein-cholesterol (HDL-c) (WMD: 3.02 mg/dL; 95% CI: -0.39, 6.43; P = 0.082). The overall effect of ALA on serum triglyceride did not reveal any significant change, but in subgroup analysis based on health status (diabetic vs. non-diabetic), ALA decreased serum triglyceride levels in both diabetic and non-diabetic groups compared with controls. This meta-analysis revealed that ALA might favorably affect lipid profile especially LDL and TC. However, for confirming these results, more studies particularly among hyperlipidemic patients are needed.
随机对照试验（RCT）已经证明，硫辛酸（ALA）可能会改变血脂谱，但结果相互矛盾。本研究的目的是进行荟萃分析以评估 ALA 对血脂谱的影响。电子数据库包括 ISI web of science、Ovid、PubMed/Medline、SCOPUS 和 Google Scholar，检索时间截至 2018 年 2 月。选择了评估 ALA 对血脂谱影响的 RCT。血清脂质浓度的加权均数差（WMD）和 95％置信区间（CI）被定义为干预效果。使用随机效应模型估计合并效应。使用 I 检验测量异质性。该方案已在 PROSPERO（编号 CRD42017072365）中注册。数据库检索共检索到 12 篇文章。与对照组相比，补充硫辛酸的受试者血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-c）水平显著降低（WMD=-10.18mg/dL；95％CI：-16.16，-4.20mg/dL；P=0.001 和 WMD=-9.22mg/dL；95％CI：-18.28，-0.16mg/dL；P=0.001），但高密度脂蛋白胆固醇（HDL-c）无明显变化（WMD：3.02mg/dL；95％CI：-0.39，6.43mg/dL；P=0.082）。ALA 对血清甘油三酯的总体影响没有显示出任何显著变化，但根据健康状况（糖尿病与非糖尿病）进行的亚组分析显示，与对照组相比，ALA 降低了糖尿病和非糖尿病组的血清甘油三酯水平。这项荟萃分析表明，ALA 可能对血脂谱特别是 LDL 和 TC 产生有利影响。然而，为了证实这些结果，需要进行更多的研究，特别是在高血脂患者中。
