Chang Rui B
Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06520, United States.
Neurosci Lett. 2019 Apr 17;698:209-216. doi: 10.1016/j.neulet.2019.01.013. Epub 2019 Jan 8.
While thermosensation from external environment has been extensively studied, physiological responses to temperature changes inside the body and the underlying regulatory mechanisms are less understood. As a critical link between body and brain that relays visceral organ information and regulates numerous physiological functions, the vagus nerve has been proposed to mediate diverse visceral thermal reflexes and indirectly regulate body temperature. However, the precise role of the vagus nerve in body thermal responses or visceral organ-related thermoregulation is still under debate due to extensive contradictory results. This data discrepancy is likely due to the high cell heterogeneity in the vagus nerve, as diverse vagal neuron types mediate numerous and sometimes opposite physiological functions. Here, we will review evidences that support and against the role of the vagus nerve in body thermosensation and thermoregulation and discuss potential future approaches for better understanding of this critical issue.
虽然对来自外部环境的温度感觉已进行了广泛研究，但对身体内部温度变化的生理反应及其潜在调节机制的了解较少。作为身体与大脑之间传递内脏器官信息并调节多种生理功能的关键纽带，迷走神经被认为可介导多种内脏热反射并间接调节体温。然而，由于存在大量相互矛盾的结果，迷走神经在身体热反应或与内脏器官相关的体温调节中的确切作用仍存在争议。这种数据差异可能是由于迷走神经中细胞高度异质性所致，因为不同类型的迷走神经元介导多种且有时相反的生理功能。在此，我们将综述支持和反对迷走神经在身体温度感觉和体温调节中作用的证据，并讨论未来为更好地理解这一关键问题可能采用的方法。
