TGF-β 信号在组织工程中的协同作用。
Synergetic roles of TGF-β signaling in tissue engineering.
机构信息
Deparment of Pharmacology, College of Medicine, University of Arizona, USA.
Deparment of Pharmacology, College of Medicine, University of Arizona, USA; Department of Chemistry and Biochemistry, University of Arizona, USA; The University of Arizona Cancer Center, USA.
出版信息
Cytokine. 2019 Mar;115:60-63. doi: 10.1016/j.cyto.2018.12.010. Epub 2019 Jan 8.
Abstract
Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration.
摘要
最近组织工程学的进展强调了具有特定于上下文的生长因子、细胞因子和各种小分子的生物材料设计，以更好地模拟天然细胞外基质 (ECM) 微环境。这些努力直接改善了细胞-细胞和细胞-ECM 相互作用，同时减轻了不良的细胞和免疫原性反应。在这篇简短的综述中，我们重点介绍转化生长因子 β (TGF-β) 信号在组织修复和再生过程中生物材料应用中的关键作用和调控。
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