促凋亡小干扰RNA与碳硅烷树枝状大分子的复合物：形成及其对癌细胞的影响

Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells.

作者信息

Krasheninina Olga A, Apartsin Evgeny K, Fuentes Elena, Szulc Aleksandra, Ionov Maksim, Venyaminova Alya G, Shcharbin Dzmitry, de la Mata F Javier, Bryszewska Maria, Gόmez Rafael

机构信息

Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia.

Departamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.

出版信息

Pharmaceutics. 2019 Jan 10;11(1):25. doi: 10.3390/pharmaceutics11010025.

This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed through the increase of the charge ratio (dendrimer/siRNA). The complexes decrease the viability of both "easy-to-transfect" cells (HeLa) and "hard-to transfect" ones (HL-60), indicating a high potential of the cationic carbosilane dendrimers for siRNA delivery into tumor cells.