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促凋亡小干扰RNA与碳硅烷树枝状大分子的复合物：形成及其对癌细胞的影响

Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells.

作者信息

Krasheninina Olga A, Apartsin Evgeny K, Fuentes Elena, Szulc Aleksandra, Ionov Maksim, Venyaminova Alya G, Shcharbin Dzmitry, de la Mata F Javier, Bryszewska Maria, Gόmez Rafael

机构信息

Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia.

Departamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.

出版信息

Pharmaceutics. 2019 Jan 10;11(1):25. doi: 10.3390/pharmaceutics11010025.

DOI:10.3390/pharmaceutics11010025
PMID:30634643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6359069/
Abstract

This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed through the increase of the charge ratio (dendrimer/siRNA). The complexes decrease the viability of both "easy-to-transfect" cells (HeLa) and "hard-to transfect" ones (HL-60), indicating a high potential of the cationic carbosilane dendrimers for siRNA delivery into tumor cells.

摘要

本文研究了阳离子碳硅烷树枝状大分子与抗癌小干扰RNA（siRNAs）的络合作用，以及所形成的络合物与HeLa和HL-60癌细胞的相互作用。通过增加电荷比（树枝状大分子/siRNA），观察到络合物的逐步形成及其性质的演变。这些络合物降低了“易于转染”的细胞（HeLa）和“难以转染”的细胞（HL-60）的活力，表明阳离子碳硅烷树枝状大分子在将siRNA递送至肿瘤细胞方面具有很高的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/bf2ae41093de/pharmaceutics-11-00025-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/9982b60bd9be/pharmaceutics-11-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/17c0ad97ea17/pharmaceutics-11-00025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/89dca8ec0501/pharmaceutics-11-00025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/462269ad9d36/pharmaceutics-11-00025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/8dae68fab8e9/pharmaceutics-11-00025-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/dd7be0380b04/pharmaceutics-11-00025-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/a7a82eb69de4/pharmaceutics-11-00025-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/bf2ae41093de/pharmaceutics-11-00025-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/9982b60bd9be/pharmaceutics-11-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/17c0ad97ea17/pharmaceutics-11-00025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/89dca8ec0501/pharmaceutics-11-00025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/462269ad9d36/pharmaceutics-11-00025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/8dae68fab8e9/pharmaceutics-11-00025-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/dd7be0380b04/pharmaceutics-11-00025-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/a7a82eb69de4/pharmaceutics-11-00025-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2b4/6359069/bf2ae41093de/pharmaceutics-11-00025-g008.jpg

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