Department of Medical Biochemistry, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Pharm Des. 2018;24(39):4605-4610. doi: 10.2174/1381612825666190110151957.
Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing. In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis, as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes the current knowledge of miRNAs' regulatory roles of PI3K/AKT signaling in CRC pathogenesis.
结直肠癌（CRC）是全球癌症死亡的主要原因，其发病率正在上升。在大多数 CRC 患者中，PI3K/AKT 信号轴过度激活。PI3K/AKT 信号的调节致癌或肿瘤抑制 microRNAs（miRNAs）调节细胞增殖、迁移、侵袭、血管生成以及结直肠癌细胞组织对化疗/放疗的耐药性。因此，PI3K/AKT/mTOR 信号的调节 miRNA 代表了新的患者诊断的新生物标志物，并从治疗后 CRC 患者获得具有临床价值的信息，以改善治疗策略。本综述总结了 miRNA 在 CRC 发病机制中对 PI3K/AKT 信号的调节作用的最新知识。
