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肺部感染的真实性:一例报告。

Authenticity of pulmonary infection: A case report.

作者信息

Meng Shuang-Shuang, Dai Zhi-Feng, Wang Hui-Chao, Li Yu-Xia, Wei Dan-Dan, Yang Rui-Lin, Lin Xu-Hong

机构信息

Department of Clinical Laboratory, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, Henan Province, China.

Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, Henan Province, China.

出版信息

World J Clin Cases. 2019 Jan 6;7(1):95-101. doi: 10.12998/wjcc.v7.i1.95.

Abstract

Pulmonary protozoal infections are rare. A 28-year-old woman was admitted to hospital with chief complains of cough, sputum, and dyspnea. The clinical laboratory tests for blood revealed an increased eosinophil percentage of 31.3% and significantly elevated total IgE. The chest computed tomography scan revealed that bilateral bronchial walls were thickening, accompanied with patchy spots scattered throughout bilateral lungs. A suspected multiflagellated protozoan was observed under a light microscope. But some different features were observed by electron microscopy, such as the orientation of flagella and nucleus. Besides, both bronchoalveolar lavage fluid and bronchoscopic brush smears underwent Gram staining and Pap staining, which revealed that numerous respiratory ciliated cells were scattered or accumulated in the sample. Finally, she was diagnosed with eosinophil pneumonia. Metronidazole, bronchodilators, and mucolytics were taken for 5 d and symptoms and pulmonary ventilation function improved. We herein report a case of chronic eosinophilic pneumonia, which was misdiagnosed as multiflagellated protozoan infection, and it is suggested that reliable diagnosis approaches are necessary, rather than clinical symptoms and morphological features.

摘要

肺部原虫感染较为罕见。一名28岁女性因咳嗽、咳痰及呼吸困难为主诉入院。血液临床实验室检查显示嗜酸性粒细胞百分比增加至31.3%,总IgE显著升高。胸部计算机断层扫描显示双侧支气管壁增厚,双侧肺野散在斑片状阴影。在光学显微镜下观察到疑似多鞭毛原虫。但电子显微镜观察到一些不同特征,如鞭毛和细胞核的取向。此外,支气管肺泡灌洗液和支气管镜刷检涂片均进行了革兰氏染色和巴氏染色,结果显示样本中有大量散在或聚集的呼吸道纤毛细胞。最终,她被诊断为嗜酸性粒细胞性肺炎。给予甲硝唑、支气管扩张剂和黏液溶解剂治疗5天,症状及肺通气功能改善。我们在此报告一例慢性嗜酸性粒细胞性肺炎,该病例曾被误诊为多鞭毛原虫感染,提示可靠的诊断方法是必要的,而非仅依靠临床症状和形态学特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab6/6327136/ee3aa1019a1b/WJCC-7-95-g001.jpg

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