Allergy Immunology Rheumatology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Curr Rheumatol Rep. 2019 Jan 14;21(2):1. doi: 10.1007/s11926-019-0800-6.
The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of oncogenes, metabolic derangements, and chronic inflammation.
As we learn more about the mechanisms of cellular aging, it has become important to ask whether accelerated cellular senescence occurs in lupus and other systemic rheumatologic diseases. Accelerated cellular aging may be one explanation for some of the excess morbidity and mortality seen in lupus patients. If so, drugs targeting cellular senescence may provide new options for preventing long-term complications such as organ failure in systemic lupus erythematosus patients.
细胞衰老的概念一直在发展。尽管最初是基于细胞系在体外的血清驱动复制研究提出的，但现在很明显，细胞衰老也会发生在体内。现在也很清楚，细胞衰老可以由多种刺激触发，如辐射、化疗、致癌基因激活、代谢紊乱和慢性炎症。
随着我们对细胞衰老机制的了解越来越多，人们开始关注细胞衰老是否会在狼疮和其他系统性风湿性疾病中加速发生。加速的细胞衰老可能是狼疮患者出现过多发病率和死亡率的部分原因。如果是这样，针对细胞衰老的药物可能为预防系统性红斑狼疮患者器官衰竭等长期并发症提供新的选择。
