Armenta Andrew M, Henkel Emily D, Ahmed Ammar M
University of Texas Medical Branch, School of Medicine, Galveston, TX, USA.
University of Texas Health Science Center at San Antonio, Long School of Medicine, San Antonio, TX, USA.
Drugs Aging. 2019 Mar;36(3):235-245. doi: 10.1007/s40266-018-00633-w.
Aging skin is subject to morphological change due to both intrinsic (skin tone, genetics, endogenous hormones) and extrinsic (chronic sun exposure, medications, exogenous pigments) factors. The broad spectrum of transformation includes both hypo- and hyperpigmentation. Although cutaneous pigmentary disorders are common in younger individuals, certain disorders are more prevalent in the geriatric population. This article reviews the epidemiology, pathophysiology, clinical appearance, treatment, and prognosis of pigmentary lesions that are predominant in the elderly.
由于内在因素(肤色、遗传、内源性激素)和外在因素(长期日晒、药物、外源性色素),老化皮肤会发生形态学变化。广泛的变化包括色素沉着不足和色素沉着过度。虽然皮肤色素沉着紊乱在年轻人中很常见,但某些紊乱在老年人群中更为普遍。本文综述了老年人中占主导地位的色素性病变的流行病学、病理生理学、临床表现、治疗及预后。