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皮肤色素类型、成因与治疗——综述

Skin Pigmentation Types, Causes and Treatment-A Review.

机构信息

Faculty of Pharmacy, Nursing and Health Professions, Birzeit University, Ramallah 00972, Palestine.

General Safety Section, General Services Department, Birzeit University, Bir Zeit 71939, Palestine.

出版信息

Molecules. 2023 Jun 18;28(12):4839. doi: 10.3390/molecules28124839.

Abstract

Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted by genetics, UV exposure, and some drugs. Patients' physical appearance, psychological health, and social functioning are all impacted by a sizable number of skin conditions that cause pigmentary abnormalities. Hyperpigmentation, where pigment appears to overflow, and hypopigmentation, where pigment is reduced, are the two major classifications of skin pigmentation. Albinism, melasma, vitiligo, Addison's disease, and post-inflammatory hyperpigmentation, which can be brought on by eczema, acne vulgaris, and drug interactions, are the most common skin pigmentation disorders in clinical practice. Anti-inflammatory medications, antioxidants, and medications that inhibit tyrosinase, which prevents the production of melanin, are all possible treatments for pigmentation problems. Skin pigmentation can be treated orally and topically with medications, herbal remedies, and cosmetic products, but a doctor should always be consulted before beginning any new medicine or treatment plan. This review article explores the numerous types of pigmentation problems, their causes, and treatments, as well as the 25 plants, 4 marine species, and 17 topical and oral medications now on the market that have been clinically tested to treat skin diseases.

摘要

人类皮肤的色素沉着和黑色素合成是非常多样化的,受到遗传、紫外线暴露和某些药物的影响。许多导致色素异常的皮肤疾病会影响患者的外貌、心理健康和社会功能。皮肤色素沉着的两种主要类型是色素过度沉着和色素减退。临床上最常见的皮肤色素沉着疾病包括白化病、黄褐斑、白癜风、艾迪生病和炎症后色素沉着过度,这些疾病可由湿疹、寻常痤疮和药物相互作用引起。针对色素沉着问题,可采用抗炎药物、抗氧化剂和抑制酪氨酸酶的药物(酪氨酸酶可阻止黑色素的生成)进行治疗。无论选择何种治疗方法,都应先咨询医生,再开始使用新的药物或治疗方案。本文综述了多种类型的色素沉着问题及其病因和治疗方法,以及目前已上市并经临床验证可用于治疗皮肤疾病的 25 种植物、4 种海洋物种和 17 种局部和口服药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/10304091/d3458e9172d8/molecules-28-04839-g003.jpg

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