患者呼吸触发的胰腺定量 T 映射。
Patient respiratory-triggered quantitative T mapping in the pancreas.
机构信息
Department of Radiology, University hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Advanced Clinical Imaging Technology, Siemens Healthcare, Switzerland.
出版信息
J Magn Reson Imaging. 2019 Aug;50(2):410-416. doi: 10.1002/jmri.26612. Epub 2019 Jan 13.
BACKGROUND
Long acquisition times and motion sensitivity limit T mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free-breathing.
PURPOSE
To test the feasibility of respiratory-triggered quantitative T analysis in the pancreas and correlate T -values with age, body mass index, pancreatic location, main pancreatic duct dilatation, and underlying pathology.
STUDY TYPE
Retrospective single-center pilot study.
POPULATION
Eighty-eight adults.
FIELD STRENGTH/SEQUENCE: Ten-fold accelerated multiecho-spin-echo 3 T MRI sequence to quantify T at 3 T.
ASSESSMENT
Two radiologists independently delineated three regions of interest inside the pancreatic head, body, and tail for each acquisition. Means and standard deviations for T values in these regions were determined. T -value variation with demographic data, intraparenchymal location, pancreatic duct dilation, and underlying pancreatic disease was assessed.
STATISTICAL TESTS
Interreader reliability was determined by calculating the interclass coefficient (ICCs). T values were compared for different pancreatic locations by analysis of variance (ANOVA). Interpatient associations between T values and demographical, clinical, and radiological data were calculated (ANOVA).
RESULTS
The accelerated T mapping sequence was successfully performed in all participants (mean acquisition time, 2:48 ± 0:43 min). Low T value variability was observed across all patients (intersubject) (head: 60.2 ± 8.3 msec, body: 63.9 ± 11.5 msec, tail: 66.8 ± 16.4 msec). Interreader agreement was good (ICC, 0.82, 95% confidence interval: 0.77-0.86). T -values differed significantly depending on age (P < 0.001), location (P < 0.001), main pancreatic duct dilatation (P < 0.001), and diffuse pancreatic disease (P < 0.03).
DATA CONCLUSION
The feasibility of accelerated T mapping at 3 T in moving abdominal organs was demonstrated in the pancreas, since T values were stable and reproducible. In the pancreatic parenchyma, T -values were significantly dependent on demographic and clinical parameters.
LEVEL OF EVIDENCE
4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:410-416.
背景
在腹部进行 T 映射时，采集时间长且对运动敏感。在 3T 下进行加速映射可能允许在自由呼吸期间对弥漫性胰腺疾病患者进行定量评估。
目的
测试在胰腺中进行呼吸触发定量 T 分析的可行性，并将 T 值与年龄、体重指数、胰腺位置、主胰管扩张和潜在病理学相关联。
研究类型
回顾性单中心试点研究。
人群
88 名成年人。
磁场强度/序列：在 3T 下对胰腺进行十倍加速多回波自旋回波 3T MRI 序列以定量 T 值。
评估
两位放射科医生分别在每个采集物中对胰腺头部、体部和尾部的三个感兴趣区域进行独立描绘。确定这些区域 T 值的平均值和标准差。评估 T 值随人口统计学数据、实质内位置、胰管扩张和潜在胰腺疾病的变化。
统计学检验
通过计算组内相关系数（ICCs）来确定读者间的可靠性。通过方差分析（ANOVA）比较不同胰腺位置的 T 值。计算 T 值与人口统计学、临床和影像学数据之间的患者间相关性（ANOVA）。
结果
加速 T 映射序列在所有参与者中均成功完成（平均采集时间为 2:48 ± 0:43 分钟）。所有患者（个体间）的 T 值变异性较低（头部：60.2 ± 8.3 msec，体部：63.9 ± 11.5 msec，尾部：66.8 ± 16.4 msec）。读者间的一致性良好（ICC，0.82，95%置信区间：0.77-0.86）。T 值根据年龄（P < 0.001）、位置（P < 0.001）、主胰管扩张（P < 0.001）和弥漫性胰腺疾病（P < 0.03）显著不同。
数据结论
在移动腹部器官中，在 3T 下进行加速 T 映射的可行性在胰腺中得到了证明，因为 T 值是稳定且可重复的。在胰腺实质中，T 值与人口统计学和临床参数显著相关。
证据水平
4 技术功效：第 1 阶段 J. Magn. Reson. Imaging 2019;50:410-416.
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