Department of Obstetrics & Gynaecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Epigenomics. 2019 Feb;11(2):147-167. doi: 10.2217/epi-2018-0190. Epub 2019 Jan 14.
As RNA, which plays a role in the regulation of endometrial receptivity, can be modulated via ceRNA mechanisms, we constructed a ceRNA network to explore potential RNA/ceRNA biomarkers indicating endometrial receptivity associated with endometriosis.
MATERIALS & METHODS: RNA sequencing was performed on eutopic endometrium from eight patients with and without endometriosis. Bioinformatics algorithms were used to predict ceRNA network and pathway analysis.
We identified an endometriosis-associated ceRNA network involving 45 pathways and four ceRNAs as potential predictive biomarkers for endometrial receptivity. Patients with endometriosis presented lower levels of progesterone receptor type B expression.
Differentially expressed RNAs and lower progesterone receptors type B levels in endometriosis might be related to the impairment of endometrial receptivity.
RNA 在调节子宫内膜容受性方面发挥作用，其可以通过 ceRNA 机制进行调控，因此我们构建了 ceRNA 网络，以探索与子宫内膜异位症相关的潜在 RNA/ceRNA 生物标志物，以指示子宫内膜容受性。
对 8 例子宫内膜异位症患者和 8 例非子宫内膜异位症患者的在位子宫内膜进行 RNA 测序。使用生物信息学算法预测 ceRNA 网络和通路分析。
我们鉴定出一个与子宫内膜异位症相关的 ceRNA 网络，涉及 45 个通路和 4 个 ceRNA，它们可能是子宫内膜容受性的潜在预测生物标志物。子宫内膜异位症患者孕激素受体 B 型表达水平较低。
子宫内膜异位症中差异表达的 RNA 和较低的孕激素受体 B 型水平可能与子宫内膜容受性受损有关。
