Department of Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Biophysics Program , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Anal Chem. 2019 Feb 19;91(4):2561-2569. doi: 10.1021/acs.analchem.8b04797. Epub 2019 Jan 30.
We describe how 4-dimensional in vivo biochemical analysis can be performed using photoacoustic contrast nanoagents that have been designed to probe both structural and chemical information in vivo, enabling noninvasive, real time, spatially resolved chemical imaging. Early chemical imaging of a patient's tumor can inform the decision of effective treatment, regarding choices of chemotherapy, radiation, or immunotherapy.
我们描述了如何使用设计用于探测体内结构和化学信息的光声对比纳米探针进行 4 维体内生化分析，从而实现非侵入性、实时、空间分辨的化学成像。对患者肿瘤的早期化学成像可以为有效治疗的决策提供信息，包括化疗、放疗或免疫治疗的选择。
