一个身份识别错误的案例：MAR-1 抗体与鼠 FcεRIα 交叉反应，与 FcγRI 和 FcγRIV 发生交叉反应。
A case of mistaken identity: The MAR-1 antibody to mouse FcεRIα cross-reacts with FcγRI and FcγRIV.
机构信息
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, Calif; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, Calif; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, Calif.
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, Calif; Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, Calif; Department of Anatomy, University of California, San Francisco, San Francisco, Calif.
出版信息
J Allergy Clin Immunol. 2019 Apr;143(4):1643-1646.e6. doi: 10.1016/j.jaci.2018.11.045. Epub 2019 Jan 10.
Abstract
This study demonstrates that the MAR-1 antibody to mouse FcepsilonRI unexpectedly binds to two Fcgamma receptors, raising concerns regarding numerous studies that used this antibody to assess the distribution and function of FcepsilonRI+ cells.
摘要
这项研究表明，MAR-1 抗体对小鼠 FcepsilonRI 的结合出乎意料地结合到两个 Fcγ 受体上，这引起了人们对众多使用该抗体来评估 FcepsilonRI+细胞分布和功能的研究的关注。
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