Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indiananpolis, IN, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Psychiatry Res Neuroimaging. 2019 Feb 28;284:21-28. doi: 10.1016/j.pscychresns.2018.12.016. Epub 2019 Jan 2.
An emergent literature suggests that resting state functional magnetic resonance imaging (rsfMRI) functional connectivity (FC) patterns are aberrant in alcohol use disorder (AUD) populations. The salience network (SAL) is an established set of brain regions prominent in salience attribution and valuation, and includes the anterior insular cortex (AIC). The SAL is thought to play a role in AUD through directing increased attention to interoceptive cues of intoxication. There is very little information on the salience network (SAL) in AUD, and, in particular, there are no data on SAL FC in currently drinking, nontreatment seeking individuals with AUD (NTS). rsfMRI data from 16 NTS and 21 social drinkers (SD) were compared using FC correlation maps from ten seed regions of interest in the bilateral AIC. As anticipated, SD subjects demonstrated greater insular FC with frontal and parietal regions. We also found that, compared to SD, NTS had higher insular FC with hippocampal and medial orbitofrontal regions. The apparent overactivity in brain networks involved in salience, learning, and behavioral control in NTS suggests possible mechanisms in the development and maintenance of AUD.
越来越多的文献表明，酒精使用障碍（AUD）患者的静息态功能磁共振成像（rsfMRI）功能连接（FC）模式异常。突显网络（SAL）是一组已确定的大脑区域，在突显归因和评估中很突出，包括前岛叶皮层（AIC）。SAL 被认为通过将注意力更多地集中在醉酒的内脏感觉线索上来发挥作用。关于 AUD 中的突显网络（SAL）的信息很少，特别是在目前饮酒但未接受治疗的 AUD 患者（NTS）中，没有关于 SAL FC 的数据。使用双侧 AIC 十个感兴趣区的 FC 相关图比较了 16 名 NTS 和 21 名社交饮酒者（SD）的 rsfMRI 数据。正如预期的那样，SD 受试者与额叶和顶叶区域的岛叶 FC 更大。我们还发现，与 SD 相比，NTS 与海马和内侧眶额区域的岛叶 FC 更高。NTS 中涉及突显、学习和行为控制的大脑网络的明显过度活跃表明，AUD 的发展和维持可能存在某些机制。
