Department of Medicine, University of Otago, Dunedin, NEW ZEALAND.
School of Physical Education, Sports and Exercises Sciences, University of Otago, Dunedin, NEW ZEALAND.
Med Sci Sports Exerc. 2019 Jun;51(6):1099-1105. doi: 10.1249/MSS.0000000000001897.
Type 2 diabetes is associated with reduced left ventricular reserve. It is unclear whether exercise training improves left ventricular function in people with type 2 diabetes.
This study aimed to determine whether 3 months of high-intensity interval training (HIIT) improves left ventricular function during exercise in adults with type 2 diabetes.
Participants performed a V˙O2peak test and received a DXA scan and total blood volume measurement at baseline. Left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular stroke volume (LVSV) were then measured at rest and during low- and moderate-intensity semirecumbent exercise in adults with type 2 diabetes before and after 3 months of HIIT (n = 11) or no training (control) (n = 5). The effects of HIIT were determined using repeated-measures ANOVA.
HIIT increased V˙O2peak by approximately 15% (P < 0.002) but did not change body composition or total blood volume. LVESV decreased and LVEDV and LVSV increased from rest to moderate-intensity exercise in both groups at baseline (all P < 0.01). Three months of HIIT increased LVEDV (P = 0.008) and LVSV (P = 0.02) at all conditions, but there was no difference in controls (all P > 0.05). HIIT augmented the reduction in LVESV from rest to moderate-intensity exercise (P < 0.04), but LVESV was unchanged in controls. Increased LVEDV explained 51% of the change in LVSV after HIIT intervention. Mitral inflow parameters and mitral annular velocities were unaffected by HIIT (all P > 0.05).
HIIT training increased the LVSV response to exercise in adults with type 2 diabetes. These data suggest that HIIT can improve LV filling and emptying during exercise and reverse early cardiac consequences of type 2 diabetes.
本研究旨在确定 3 个月高强度间歇训练（HIIT）是否能改善 2 型糖尿病患者运动时的左心室功能。
参与者在基线时进行了 VO2peak 测试，并接受了 DXA 扫描和总血容量测量。然后，在接受 3 个月 HIIT（n=11）或无训练（对照组）（n=5）之前和之后，测量 2 型糖尿病成人在低强度和中强度半卧位运动期间的左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）和左心室每搏输出量（LVSV）。使用重复测量方差分析确定 HIIT 的效果。
HIIT 使 VO2peak 增加了约 15%（P<0.002），但没有改变身体成分或总血容量。在两组中，LVESV 从静息状态到中等强度运动时均降低，而 LVEDV 和 LVSV 从静息状态开始增加（所有 P<0.01）。在所有条件下，3 个月的 HIIT 均增加了 LVEDV（P=0.008）和 LVSV（P=0.02），但对照组无差异（所有 P>0.05）。HIIT 增强了从静息状态到中等强度运动时 LVESV 的减少（P<0.04），但对照组 LVESV 无变化。HIIT 干预后 LVSV 的变化中，LVEDV 增加解释了 51%。HIIT 对二尖瓣流入参数和二尖瓣环速度没有影响（所有 P>0.05）。
HIIT 训练增加了 2 型糖尿病患者运动时的 LVSV 反应。这些数据表明，HIIT 可以改善运动时的 LV 充盈和排空，并逆转 2 型糖尿病的早期心脏后果。
