印度登革热的流行病学，基于实验室监测数据，2014-2017 年。

Epidemiology of dengue fever in India, based on laboratory surveillance data, 2014-2017.

机构信息

ICMR - National Institute of Epidemiology, Chennai, Tamil Nadu, India.

出版信息

Int J Infect Dis. 2019 Jul;84S:S10-S14. doi: 10.1016/j.ijid.2019.01.004. Epub 2019 Jan 11.

DOI:10.1016/j.ijid.2019.01.004

PMID:30641202

Abstract

OBJECTIVES

The Indian Council of Medical Research and the Department of Health Research have established a network of Virus Research and Diagnostic Laboratories (VRDL) to strengthen laboratory capacity in India. We analyzed the data generated by the 52 VRDLs during 2014-2017 to describe the epidemiology of dengue fever (DF) in India.

METHODS

As per the laboratory protocol, suspected DF patients reporting to various hospitals where VRDLs are located, or samples from suspected DF outbreaks are investigated for the presence of NS1 antigen or IgM antibodies against dengue. The data were analyzed to describe the distribution of DF by time (month and year), place (district and state) and person (age and sex) characteristics.

RESULTS

Between 2014-2017, VRDLs investigated 211,432 suspected DF patients, 28.4% of whom were serologically confirmed. The median age of dengue positive patients was 25 years (IQR: 16-36). Dengue positivity was significantly higher among males. The mean monthly dengue positivity ranged from 7.7% to 37%, with higher positivity reported during September and October months. VRDLs provided diagnosis to 190 suspected outbreaks.

CONCLUSIONS

The data from the VRDL network indicate dengue was the etiology in one-fourth of AFI cases. Dengue was the second commonest etiology of suspected outbreaks diagnosed by VRDLs.

摘要

目的

印度医学研究理事会和卫生研究部已经建立了一个病毒研究和诊断实验室（VRDL）网络，以加强印度的实验室能力。我们分析了 2014-2017 年期间 52 个 VRDL 生成的数据，以描述印度登革热（DF）的流行病学。

方法

根据实验室方案，向设有 VRDL 的各个医院报告的疑似 DF 患者或疑似 DF 暴发的样本中，调查 NS1 抗原或针对登革热的 IgM 抗体的存在。对数据进行分析，以描述按时间（月份和年份）、地点（区和邦）和人员（年龄和性别）特征分布的 DF。

结果

在 2014-2017 年期间，VRDL 调查了 211,432 例疑似 DF 患者，其中 28.4%经血清学确认。登革热阳性患者的中位年龄为 25 岁（IQR：16-36）。男性登革热阳性率明显更高。每月登革热阳性率从 7.7%到 37%不等，9 月和 10 月报告的阳性率更高。VRDL 为 190 例疑似暴发提供了诊断。