• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗菌蛋白是否有助于在抗生素后时代之初克服潜在的抗真菌危机？

Do Antimicrobial Proteins Contribute to Overcoming the Hidden Antifungal Crisis at the Dawn of a Post-Antibiotic Era?

作者信息

Galgóczy László, Marx Florentine

机构信息

Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, Temesvári krt. 62, H-6726 Szeged, Hungary.

Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary.

出版信息

Microorganisms. 2019 Jan 11;7(1):16. doi: 10.3390/microorganisms7010016.

DOI:10.3390/microorganisms7010016
PMID:30641886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6352135/
Abstract

The incidence of fungal infections has been grossly underestimated in the past decades as a consequence of poor identification techniques and a lack of regular epidemiologic surveys in low- and middle-income countries [...].

摘要

在过去几十年中，由于低收入和中等收入国家的鉴定技术不佳以及缺乏定期的流行病学调查，真菌感染的发病率被严重低估了[……]。

相似文献

1
Do Antimicrobial Proteins Contribute to Overcoming the Hidden Antifungal Crisis at the Dawn of a Post-Antibiotic Era?抗菌蛋白是否有助于在抗生素后时代之初克服潜在的抗真菌危机？
Microorganisms. 2019 Jan 11;7(1):16. doi: 10.3390/microorganisms7010016.
2
Vesicoureteral Reflux膀胱输尿管反流
3
Antifungal Use and Resistance in a Lower-Middle-Income Country: The Case of Lebanon.中低收入国家的抗真菌药物使用与耐药性：以黎巴嫩为例。
Antibiotics (Basel). 2023 Sep 6;12(9):1413. doi: 10.3390/antibiotics12091413.
4
Overcoming clinical challenges in the management of invasive fungal infections in low- and middle-income countries (LMIC).应对低收入和中等收入国家侵袭性真菌感染管理中的临床挑战。
Expert Rev Anti Infect Ther. 2023 Jul-Dec;21(10):1057-1070. doi: 10.1080/14787210.2023.2257895. Epub 2023 Sep 12.
5
Candida and candidaemia. Susceptibility and epidemiology.念珠菌与念珠菌血症。药敏性与流行病学。
Dan Med J. 2013 Nov;60(11):B4698.
6
Antimicrobial resistance: are we at the dawn of the post-antibiotic era?抗生素耐药性：我们正处于后抗生素时代的黎明吗？
J R Coll Physicians Edinb. 2016 Sep;46(3):150-156. doi: 10.4997/JRCPE.2016.302.
7
Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era.利用无机纳米颗粒在抗微生物药物耐药时代对抗真菌感染。
Acta Biomater. 2023 Mar 1;158:56-79. doi: 10.1016/j.actbio.2023.01.019. Epub 2023 Jan 11.
8
Strategies to improve antibiotic access and a way forward for lower middle-income countries.提高抗生素可及性的策略及中低收入国家的前进道路。
J Antimicrob Chemother. 2024 Jan 3;79(1):1-10. doi: 10.1093/jac/dkad291.
9
Hybrid combinations containing natural products and antimicrobial drugs that interfere with bacterial and fungal biofilms.包含天然产物和干扰细菌及真菌生物膜的抗菌药物的混合组合。
Phytomedicine. 2017 Dec 15;37:14-26. doi: 10.1016/j.phymed.2017.10.021. Epub 2017 Nov 23.
10
Potential Treatment Options in a Post-antibiotic Era.后抗生素时代的潜在治疗选择。
Adv Exp Med Biol. 2018;1052:51-61. doi: 10.1007/978-981-10-7572-8_5.

引用本文的文献

1
Design, synthesis and antifungal activity of novel matrine-hydroxamic acid derivatives containing benzene sulfonamide.含苯磺酰胺的新型苦参碱-异羟肟酸衍生物的设计、合成及抗真菌活性
RSC Adv. 2025 May 19;15(21):16510-16524. doi: 10.1039/d5ra01689d. eCollection 2025 May 15.
2
Confirmation of the Disulfide Connectivity and Strategies for Chemical Synthesis of the Four-Disulfide-Bond-Stabilized Antifungal Protein, AFP.确认二硫键连接和四硫键稳定抗真菌蛋白 AFP 的化学合成策略。
J Nat Prod. 2023 Apr 28;86(4):782-790. doi: 10.1021/acs.jnatprod.2c00954. Epub 2023 Feb 27.
3
Potential of Antifungal Proteins (AFPs) to Control Postharvest Fruit Decay.抗真菌蛋白（AFPs）控制采后果实腐烂的潜力
J Fungi (Basel). 2021 Jun 4;7(6):449. doi: 10.3390/jof7060449.
4
The Antifungal Protein AfpB Induces Regulated Cell Death in Its Parental Fungus .抗菌蛋白 AfpB 诱导其亲代真菌发生细胞程序性死亡。
mSphere. 2020 Aug 26;5(4):e00595-20. doi: 10.1128/mSphere.00595-20.
5
The Myosin Motor Domain-Containing Chitin Synthases Are Involved in Cell Wall Integrity and Sensitivity to Antifungal Proteins in .含肌球蛋白运动结构域的几丁质合酶参与了……的细胞壁完整性及对抗真菌蛋白的敏感性
Front Microbiol. 2019 Oct 18;10:2400. doi: 10.3389/fmicb.2019.02400. eCollection 2019.

本文引用的文献

1
Structure and Synthesis of Antifungal Disulfide β-Strand Proteins from Filamentous Fungi.丝状真菌抗真菌二硫键β-链蛋白的结构与合成
Microorganisms. 2018 Dec 27;7(1):5. doi: 10.3390/microorganisms7010005.
2
Differential roles, crosstalk and response to the Antifungal Protein AfpB in the three Mitogen-Activated Protein Kinases (MAPK) pathways of the citrus postharvest pathogen Penicillium digitatum.柑橘采后病原菌指状青霉中三种丝裂原活化蛋白激酶（MAPK）途径对真菌蛋白 AfpB 的差异作用、串扰和响应。
Fungal Genet Biol. 2019 Mar;124:17-28. doi: 10.1016/j.fgb.2018.12.006. Epub 2018 Dec 21.
3
Efficient production of antifungal proteins in plants using a new transient expression vector derived from tobacco mosaic virus.利用一种新型的源自烟草花叶病毒的瞬时表达载体在植物中高效生产抗真菌蛋白。
Plant Biotechnol J. 2019 Jun;17(6):1069-1080. doi: 10.1111/pbi.13038. Epub 2018 Dec 6.
4
Applicability of Neosartorya fischeri Antifungal Protein 2 (NFAP2) in Treatment of Vulvovaginal Candidiasis.棘孢木霉抗真菌蛋白 2（NFAP2）在治疗外阴阴道念珠菌病中的适用性。
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01777-18. Print 2019 Feb.
5
Three Antifungal Proteins From : Different Patterns of Production and Antifungal Activity.来自三种抗真菌蛋白：不同的产生模式和抗真菌活性。
Front Microbiol. 2018 Oct 5;9:2370. doi: 10.3389/fmicb.2018.02370. eCollection 2018.
6
Rational Design and Biotechnological Production of Novel AfpB-PAF26 Chimeric Antifungal Proteins.新型AfpB-PAF26嵌合抗真菌蛋白的合理设计与生物技术生产
Microorganisms. 2018 Oct 15;6(4):106. doi: 10.3390/microorganisms6040106.
7
A Computational Modeling Approach Predicts Interaction of the Antifungal Protein AFP from with Fungal Membranes via Its γ-Core Motif.一种计算建模方法预测了来自 真菌的抗真菌蛋白 AFP 通过其 γ-核心基序与真菌膜的相互作用。
mSphere. 2018 Oct 3;3(5):e00377-18. doi: 10.1128/mSphere.00377-18.
8
New 19-Residue Peptaibols from Clade Viride.来自绿色进化枝的新型19残基肽菌素
Microorganisms. 2018 Aug 12;6(3):85. doi: 10.3390/microorganisms6030085.
9
The Evolutionary Conserved γ-Core Motif Influences the Anti- Activity of the Antifungal Protein PAF.进化保守的γ-核心基序影响抗真菌蛋白PAF的抗菌活性。
Front Microbiol. 2018 Jul 20;9:1655. doi: 10.3389/fmicb.2018.01655. eCollection 2018.
10
Inhibitory Effect of PgAFP and Protective Cultures on Growth and Aflatoxins Production on Dry-Fermented Sausage and Cheese.PgAFP和保护性培养物对干发酵香肠和奶酪生长及黄曲霉毒素产生的抑制作用
Microorganisms. 2018 Jul 13;6(3):69. doi: 10.3390/microorganisms6030069.