Rajaei Elham, Jalali Mohammad Taha, Shahrabi Saeid, Asnafi Ali Amin, Pezeshki Seyed Mohammad Sadegh
Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hyperlipidemia Research Center, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Rheumatol Rev. 2019;15(4):269-276. doi: 10.2174/1573397115666190115143226.
The process of antigen presentation to immune cells is an undeniable contributor to the pathogenesis of autoimmune diseases. Different studies have indicated several factors that are related to autoimmunity. Human Leukocyte Antigens (HLAs) are among such factors, which have a key role in autoimmunity because of their involvement in antigen presentation process.
Relevant English language literature was searched and retrieved from Google Scholar search engine and PubMed database (1996-2018). The following keywords were used: "Human leukocyte antigen", "Behcet's syndrome", "Rheumatoid arthritis", "Systemic lupus erythematosus", "Type 1 diabetes", "Celiac Disease" and "Autoimmunity".
There is a strong association between HLA alleles and autoimmune diseases. For instance, HLA-B alleles and Behcet's syndrome are strongly correlated, and systemic lupus erythematosus and Type 1 diabetes are related to HLA-DQA1 and HLA-DQB1, respectively.
Association between numerous HLA alleles and autoimmune diseases may justify and rationalize their use as biomarkers as well as possible diagnostic laboratory parameters.
抗原呈递给免疫细胞的过程无疑是自身免疫性疾病发病机制的一个促成因素。不同的研究表明了几个与自身免疫相关的因素。人类白细胞抗原（HLA）就是其中的因素之一，由于其参与抗原呈递过程，在自身免疫中起着关键作用。
从谷歌学术搜索引擎和PubMed数据库（1996 - 2018年）中搜索并检索相关英文文献。使用了以下关键词：“人类白细胞抗原”、“白塞病”、“类风湿性关节炎”、“系统性红斑狼疮”、“1型糖尿病”、“乳糜泻”和“自身免疫”。
HLA等位基因与自身免疫性疾病之间存在密切关联。例如，HLA - B等位基因与白塞病密切相关，系统性红斑狼疮和1型糖尿病分别与HLA - DQA1和HLA - DQB1相关。
众多HLA等位基因与自身免疫性疾病之间的关联可能证明将其用作生物标志物以及可能的诊断实验室参数是合理的。
